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National Institutes of Health Stroke Scale for prediction of proximal vessel occlusion in anterior circulation stroke
Source: International Journal of Stroke - July 23, 2015 Category: Neurology Authors: Jan F. Scheitz, Hebun Erdur, Serdar Tütüncü, Jochen B. Fiebach, Heinrich J. Audebert, Matthias Endres, Christian H. Nolte Tags: Letter to the editor Source Type: research

Thrombectomy in patients ineligible for iv tPA (THRILL)
DiscussionWhether mechanical thrombectomy in patients with acute ischemic stroke who are not eligible for intravenous thrombolysis with recombinant tissue plasminogen activator improves clinical outcomes is unclear. ‘Thrombectomy in patients ineligible for iv tPA’ may change clinical practice by providing evidence of an effective and safe treatment for such patients.
Source: International Journal of Stroke - June 4, 2015 Category: Neurology Authors: Martin Bendszus, Götz Thomalla, Michael Knauth, Werner Hacke, Susanne Bonekamp, Jens Fiehler Tags: Protocol Source Type: research

Intra‐arterial bone marrow mononuclear cells (BM‐MNCs) transplantation in acute ischemic stroke (IBIS trial): protocol of a phase II, randomized, dose‐finding, controlled multicenter trial
DiscussionThis is the first trial to explore efficacy of different doses of intra‐arterial bone marrow mononuclear cell in moderate‐to‐severe acute ischemic stroke patients. The trial is registered as NCT02178657.
Source: International Journal of Stroke - June 4, 2015 Category: Neurology Authors: Francisco Moniche, Irene Escudero, Elena Zapata‐Arriaza, María Usero‐Ruiz, María Prieto‐León, Javier Torre, Miguel‐Angel Gamero, Jose Antonio Tamayo, Juan‐José Ochoa‐Sepúlveda, José Maestre, Magdalena Carmona, Pilar Piñero, Cristina Cal Tags: Protocol Source Type: research

Solitaire™ with the Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke (SWIFT PRIME) trial: protocol for a randomized, controlled, multicenter study comparing the Solitaire revascularization device with IV tPA with IV tPA alone in acute ischemic stroke
RationaleEarly reperfusion in patients experiencing acute ischemic stroke is critical, especially for patients with large vessel occlusion who have poor prognosis without revascularization. Solitaire™ stent retriever devices have been shown to immediately restore vascular perfusion safely, rapidly, and effectively in acute ischemic stroke patients with large vessel occlusions. AimThe aim of the study was to demonstrate that, among patients with large vessel, anterior circulation occlusion who have received intravenous tissue plasminogen activator, treatment with Solitaire revascularization devices reduces degree of disab...
Source: International Journal of Stroke - March 16, 2015 Category: Neurology Authors: Jeffrey L. Saver, Mayank Goyal, Alain Bonafe, Hans‐Christoph Diener, Elad I. Levy, Vitor M. Pereira, Gregory W. Albers, Christophe Cognard, David J. Cohen, Werner Hacke, Olav Jansen, Tudor G. Jovin, Heinrich P. Mattle, Raul G. Nogueira, Adnan H. Siddiqu Tags: Protocols Source Type: research

Daily National Institutes of Health Stroke Scale examinations at stroke centers: why not do them?
The National Institutes of Health Stroke Scale was originally designed to stratify patients according to stroke severity for clinical trials, and now it is used to predict disposition and prognosticate functional outcome. Many researchers have also adopted it to trend patient progress over time and detect early neurologic deterioration. However, few investigators have reported its utility in monitoring the daily progress of patients hospitalized for stroke. In the present article, the authors discuss the advantages of daily National Institutes of Health Stroke Scale assessments and our clinical experience with this invaluable tool.
Source: International Journal of Stroke - January 19, 2015 Category: Neurology Authors: James E. Siegler, Sheryl Martin‐Schild Tags: Leading opinion Source Type: research

National Institutes of Health Stroke Scale object naming test in a non‐American English‐speaking population
Source: International Journal of Stroke - September 18, 2014 Category: Neurology Authors: Meghan Burns, Kate Somers, Paul McElwaine, Joseph Harbison Tags: Letter to the editor Source Type: research

EuroHYP‐1: European multicenter, randomized, phase III clinical trial of therapeutic hypothermia plus best medical treatment vs. best medical treatment alone for acute ischemic stroke
DiscussionWith 750 patients per intervention group, this trial has 90% power to detect 7% absolute improvement at the 5% significance level. The full trial protocol is available at http://www.eurohyp1.eu. ClinicalTrials.gov Identifier: NCT01833312.
Source: International Journal of Stroke - May 15, 2014 Category: Neurology Authors: H. Bart Worp, Malcolm R. Macleod, Philip M. W. Bath, Jacques Demotes, Isabelle Durand‐Zaleski, Bernd Gebhardt, Christian Gluud, Rainer Kollmar, Derk W. Krieger, Kennedy R. Lees, Carlos Molina, Joan Montaner, Risto O. Roine, Jesper Petersson, Dimitre Sta Tags: Protocols Source Type: research

Human choriogonadotropin and epoetin alfa in acute ischemic stroke patients (REGENESIS‐LED trial)
DiscussionAdministration of human choriogonadotropin alfa followed by erythropoietin is safe after a new ischemic stroke. At the doses studied, placebo and active groups did not differ significantly in neurological recovery. Study limitations, such as the use of multiple assessors, differences in rehabilitation care, and being underpowered to show efficacy, are discussed.
Source: International Journal of Stroke - February 1, 2014 Category: Neurology Authors: Steven C. Cramer, Michael D. Hill, Tags: Research Source Type: research

Current status of acute stroke management in Korea: a report on a multicenter, comprehensive acute stroke registry
There are limited data on the utilization of diagnostics and the variation of treatments at the national level in acute stroke care. Clinical Research Center for Stroke – 5th division stroke registry aimed to describe stroke statistics and quality of care in Korea and to implement quality indicators. Clinical Research Center for Stroke – 5th division registry was established in April 2008 and covers pretreatment demographics, medical and stroke severity measures, diagnostic evaluation, hyperacute revascularization, in‐hospital management, discharge disposition, quality indicators, and long‐term functional outcomes....
Source: International Journal of Stroke - November 21, 2013 Category: Neurology Authors: Beom Joon Kim, Moon‐Ku Han, Tai Hwan Park, Sang‐Soon Park, Kyung Bok Lee, Byung‐Chul Lee, Kyung‐Ho Yu, Jae Kwan Cha, Dae‐Hyun Kim, Jun Lee, Soo Joo Lee, Youngchai Ko, Jong‐Moo Park, Kyusik Kang, Yong‐Jin Cho, Keun‐Sik Hong, Ki‐Hyun Cho, Tags: Panorama Source Type: research

A multicenter, randomized, controlled study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits with Intra‐Arterial therapy (EXTEND‐IA)
Background and HypothesisThrombolysis with tissue plasminogen activator is proven to reduce disability when given within 4·5 h of ischemic stroke onset. However, tissue plasminogen activator only succeeds in recanalizing large vessel arterial occlusion in a minority of patients. We hypothesized that anterior circulation ischemic stroke patients, selected with ‘dual target’ vessel occlusion and evidence of salvageable brain using computed tomography or magnetic resonance imaging ‘mismatch’ within 4·5 h of onset, would have improved reperfusion and early neurological improvement when treated with intra‐arteri...
Source: International Journal of Stroke - November 10, 2013 Category: Neurology Authors: Bruce C. V. Campbell, Peter J. Mitchell, Bernard Yan, Mark W. Parsons, Søren Christensen, Leonid Churilov, Richard J. Dowling, Helen Dewey, Mark Brooks, Ferdinand Miteff, Christopher Levi, Martin Krause, Timothy J. Harrington, Kenneth C. Faulder, Brendan Tags: Protocols Source Type: research

REVASCAT: a randomized trial of revascularization with SOLITAIRE FR® device vs. best medical therapy in the treatment of acute stroke due to anterior circulation large vessel occlusion presenting within eight‐hours of symptom onset
REVASCAT is a prospective, multicenter, randomized trial seeking to establish whether subjects meeting following main inclusion criteria: age 18‐80, baseline National Institutes of Health Stroke Scale ≥6, evidence of intracranial internal carotid artery or proximal (M1 segment) middle cerebral artery occlusion, Alberta Stroke Program Early Computed Tomography score of >7 on non‐contrast CT or >6 on diffusion‐weighted magnetic resonance imaging , ineligible for or with persistent occlusion after intravenous alteplase and procedure start within 8 hours from symptom onset, have higher rates of favorable outcome ...
Source: International Journal of Stroke - November 10, 2013 Category: Neurology Authors: Carlos A. Molina, Angel Chamorro, Àlex Rovira, Angeles Miquel, Joaquin Serena, Luis San Roman, Tudor G. Jovin, Antoni Davalos, Erik Cobo Tags: Protocols Source Type: research

The Determinants of Dementia After Stroke (DEDEMAS) Study: protocol and pilot data
This study will provide insights into the mechanisms of poststroke dementia and hold the potential to identify novel diagnostic markers and targets for preventive therapies. The study is registered at http://www.clinicaltrials.gov (NCT01334749) and will be extended as a multicenter study starting 2013.
Source: International Journal of Stroke - July 9, 2013 Category: Neurology Authors: Frank A. Wollenweber, Vera Zietemann, Axel Rominger, Christian Opherk, Anna Bayer‐Karpinska, Andreas Gschwendtner, Lisa Coloma Andrews, Katharina Bürger, Marco Duering, Martin Dichgans Tags: Protocols Source Type: research

Pattern of individual National Institutes of Health Stroke Scale item improvements after stroke
Source: International Journal of Stroke - June 20, 2013 Category: Neurology Authors: Askiel Bruno, Cynthia S. Johnson Tags: Letter to the editor Source Type: research

The Stroke Hyperglycemia Insulin Network Effort (SHINE) trial protocol: a randomized, blinded, efficacy trial of standard vs. intensive hyperglycemia management in acute stroke
DiscussionThis trial will provide important novel information about preferred management of acute ischemic stroke patients with hyperglycemia. It will determine the potential benefits and risks of intensive glucose control during acute stroke.
Source: International Journal of Stroke - March 19, 2013 Category: Neurology Authors: Askiel Bruno, Valerie L. Durkalski, Christiana E. Hall, Rattan Juneja, William G. Barsan, Scott Janis, William J. Meurer, Amy Fansler, Karen C. Johnston, Tags: Protocol Source Type: research

CHIMES‐I: sub‐group analyzes of the effects of NeuroAiD according to baseline brain imaging characteristics among patients randomized in the CHIMES study
RationaleThe clinical effects of neuroprotective and/or neurorestorative therapies may vary according to location and size of the ischemic injury. Imaging techniques can be useful in stratifying patients for trials that may be beneficial against particular ischemic lesion characteristics. AimTo test the hypothesis that the efficacy of NeuroAiD compared with placebo in improving functional outcome and reducing neurological deficit in patients with cerebral infarction of intermediate severity varies between sub‐groups of patients randomized in the main Chinese Medicine Neuroaid Efficacy on Stroke study when categorized acc...
Source: International Journal of Stroke - March 19, 2013 Category: Neurology Authors: Jose C. Navarro, Christopher Chen Li Hsian, Pedro Danilo J. Lagamayo, Melodia B. Geslani, Gaik Bee Eow, Niphon Poungvarin, Asita Silva, Lawrence K. S. Wong, N. Venketasubramanian, Tags: Protocol Source Type: research