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Testing devices for the prevention and treatment of stroke and its complications
We are entering a challenging but exciting period when many new interventions may appear for stroke based on the use of devices. Hopefully these will lead to improved outcomes at a cost that can be afforded in most parts of the world. Nevertheless, it is vital that lessons are learnt from failures in the development of pharmacological interventions (and from some early device studies), including inadequate preclinical testing, suboptimal trial design and analysis, and underpowered studies. The device industry is far more disparate than that seen for pharmaceuticals; companies are very variable in size and experience in str...
Source: International Journal of Stroke - July 17, 2014 Category: Neurology Authors: Philip M. Bath, Michael Brainin, Chloe Brown, Bruce Campbell, Stephen M. Davis, Geoffrey A. Donnan, Gary A. Ford, Werner Hacke, Cynthia Iglesias, Kennedy R. Lees, Stacey S. Pugh, Jeff L. Saver, Peter D. Schellinger, Thomas Truelsen Tags: Opinion Source Type: research

Edaravone improves functional and structural outcomes in animal models of focal cerebral ischemia: A systematic review
Edaravone has been used in patients with acute ischemic stroke in Japan for over 10 years but does not have marketing authorization in Europe or America. Either patients in Europe and America are not receiving an effective treatment, or those in Asia are being given a treatment which is not effective. Finding out which of these is true will require further clinical trials, and a better understanding of its efficacy in animal models may help inform the design of those trials so that it might be tested under conditions where there is the greatest prospect of success. We systematically reviewed the efficacy of edaravone in an...
Source: International Journal of Stroke - October 22, 2013 Category: Neurology Authors: Simiao Wu, Emily Sena, Kieren Egan, Malcolm Macleod, Gillian Mead Tags: Systematic Review Source Type: research