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Ischemic stroke on optimal anticoagulation with novel‐oral anticoagulants compared with warfarin
Source: International Journal of Stroke - July 23, 2015 Category: Neurology Authors: Bum Joon Kim, Hyun Goo Kang, Deok Hee Lee, Dong‐Wha Kang, Jong S. Kim, Sun U. Kwon Tags: Letter to the editor Source Type: research

Antithrombotic treatment at onset of stroke with atrial fibrillation, functional outcome, and fatality: a systematic review and meta‐analysis
ConclusionsTherapeutic International Normalized Ratio at stroke onset was associated with early and late improved survival and functional recovery suggesting sustained benefit for warfarin anticoagulation for stroke outcome in atrial fibrillation patients. Long‐term outcome data following stroke in patients taking new oral anticoagulants is required.
Source: International Journal of Stroke - March 22, 2015 Category: Neurology Authors: Niamh Hannon, Ethem M. Arsava, Heinrich J. Audebert, Hakan Ay, Morgan Crowe, Danielle Ní Chróinín, Karen Furie, Catherine McGorrian, Noa Molshatzki, Sean Murphy, Imelda Noone, Martin O'Donnell, Johannes Schenkel, Kit M. Tan, David Tanne, Peter J. Kelly Tags: Research Source Type: research

Oral direct thrombin inhibitor as an alternative in the management of cerebral venous thrombosis: a series of 15 patients
ConclusionsWe report the largest series of cerebral vein thrombosis patients treated with dabigatran. Clinical outcome was excellent in most patients and not different from other studies. Dabigatran could possibly be considered an alternative to warfarin; nevertheless, further prospective assessment with randomized controlled studies is warranted.
Source: International Journal of Stroke - February 1, 2015 Category: Neurology Authors: Marcelo D. Mendonça, Raquel Barbosa, Vera Cruz‐e‐Silva, Sofia Calado, Miguel Viana‐Baptista Tags: Research Source Type: research

Trends in oral anticoagulant choice for acute stroke patients with nonvalvular atrial fibrillation in Japan: The SAMURAI‐NVAF Study
ConclusionsWarfarin use at acute hospital discharge was still common in the initial years after approval of nonvitamin K antagonist oral anticoagulants, although nonvitamin K antagonist oral anticoagulant users increased gradually. The index stroke was milder and ischemia‐risk indices were lower in nonvitamin K antagonist oral anticoagulant users than in warfarin users. Early initiation of nonvitamin K antagonist oral anticoagulants seemed safe.
Source: International Journal of Stroke - January 12, 2015 Category: Neurology Authors: Kazunori Toyoda, Shoji Arihiro, Kenichi Todo, Hiroshi Yamagami, Kazumi Kimura, Eisuke Furui, Tadashi Terasaki, Yoshiaki Shiokawa, Kenji Kamiyama, Shunya Takizawa, Satoshi Okuda, Yasushi Okada, Tomoaki Kameda, Yoshinari Nagakane, Yasuhiro Hasegawa, Hiroshi Tags: Research Source Type: research

Rationale and design of Triple AXEL: trial for early anticoagulation in acute ischemic stroke patients with nonvalvular atrial fibrillation
DiscussionThe results of this proof‐of‐concept trial will guide go/no‐go decision to a large phase 3 confirmatory trial.
Source: International Journal of Stroke - October 26, 2014 Category: Neurology Authors: Keun‐Sik Hong, Yun Jung Choi, Sun U. Kwon, Tags: Protocols Source Type: research

Novel oral anticoagulants: A focused review for stroke physicians
Novel oral anticoagulants provide an effective and convenient alternative to warfarin for stroke prevention in patients with atrial fibrillation. However, novel anticoagulants also present new challenges for stroke physicians, such as measurement of anticoagulant effect in emergency situations, use of thrombolysis in acute ischemic stroke, optimal timing of introduction of novel anticoagulants following acute ischemic stroke, and management of intracerebral hemorrhage. In this review, we propose pragmatic approaches to dealing with challenging management issues that will face stroke physicians who care for patients with ac...
Source: International Journal of Stroke - October 22, 2013 Category: Neurology Authors: Emer R. McGrath, John W. Eikelboom, Moira K. Kapral, Martin J. O'Donnell Tags: Review Source Type: research

Efficacy and safety of warfarin vs. antiplatelet therapy in patients with systolic heart failure and sinus rhythm: a systematic review and meta‐analysis of randomized controlled trials
ConclusionsWarfarin as compared with antiplatelet therapy reduces risk of ischemic stroke, does not significantly affect death, myocardial infarction, hospitalization due to heart failure or intracranial hemorrhage and increases major hemorrhage in heart failure patients who are in sinus rhythm.
Source: International Journal of Stroke - March 19, 2013 Category: Neurology Authors: Aaron YL. Liew, John W. Eikelboom, Stuart J. Connolly, Martin O' Donnell, Robert G. Hart Tags: Systematic Review Source Type: research

Anaemia on admission is associated with more severe intracerebral haemorrhage and worse outcomes
ConclusionsAnaemia on admission is associated with greater intracerebral haemorrhage severity and worse outcomes. The utility of transfusion remains unclear in this setting.
Source: International Journal of Stroke - March 7, 2013 Category: Neurology Authors: Miguel Bussière, Meera Gupta, Mukul Sharma, Dar Dowlatshahi, Jiming Fang, Rajat Dhar, Tags: Research Source Type: research