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The Dutch String‐of‐Pearls Stroke Study: Protocol of a large prospective multicenter genetic cohort study
BackgroundIn the last couple of years, genome‐wide association studies have largely altered the scope in genetic research in diseases in which both environmental and genetic risk factors contribute to the disease. To date, the genetic risk loci identified in stroke have lagged behind those in other complex diseases, possibly because of the heterogeneity of stroke phenotypes. Sufficiently large cohorts with well‐defined and detailed phenotyping of stroke patients are needed to identify additional genetic risk loci. DesignThe String‐of‐Pearls Institute is a unique partnership between all eight University Medical Cent...
Source: International Journal of Stroke - August 1, 2014 Category: Neurology Authors: Paul J. Nederkoorn, Ewoud J. Dijk, Peter J. Koudstaal, Gert‐Jan Luijckx, Robert J. Oostenbrugge, Marieke C. Visser, Marieke J. H. Wermer, Ynte M. Ruigrok, Ale Algra, L. Jaap Kappelle, Tags: Protocols Source Type: research

Age‐ and gender‐specific time trend in risk of death of patients admitted with aneurysmal subarachnoid hemorrhage in the Netherlands
ConclusionsThe decrease in risk of death for patients admitted in the Netherlands with subarachnoid hemorrhage is overall considerable, but unevenly distributed over age and gender. Further research should focus on reasons for improved survival (improved diagnostics, improved treatment) and reasons why improvement has not occurred for women and for patients in older age categories.
Source: International Journal of Stroke - March 12, 2013 Category: Neurology Authors: Dennis J. Nieuwkamp, Ilonca Vaartjes, Ale Algra, Michiel L. Bots, Gabriël J. E. Rinkel Tags: Research Source Type: research