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Cerebrovascular correlates of vitamin D deficiency in older adults living near the Equator: results from the Atahualpa Project
This study shows an association of vitamin D deficiency with diffuse subcortical brain damage in older adults living in a tropical region. Lack of awareness of the importance of vitamin D deficiency might be one of the factors influencing the high prevalence of white matter hyperintensities of presumed vascular origin in underserved Latin American populations.
Source: International Journal of Stroke - August 28, 2015 Category: Neurology Authors: Oscar H. Del Brutto, Robertino M. Mera, Jorge Macias, Gabriela Morales, Mauricio Zambrano Tags: Panorama Source Type: research

The association of ankle‐brachial index with silent cerebral small vessel disease: results of the Atahualpa Project
ConclusionsIn this population‐based study conducted in rural Ecuador, apparently healthy individuals aged ≥60 years with ankle‐brachial index values ≤0·90 and ≥1·4 are almost four times more likely to have a silent lacunar infarct. Ankle‐brachial index screening might allow recognition of asymptomatic people who need further investigation and preventive therapy.
Source: International Journal of Stroke - January 12, 2015 Category: Neurology Authors: Oscar H. Del Brutto, Mark J. Sedler, Robertino M. Mera, Julio Lama, Jadry A. Gruen, Kelsie J. Phelan, Elizabeth H. Cusick, Mauricio Zambrano, David L. Brown Tags: Research Source Type: research

White matter hyperintensities of presumed vascular origin: a population‐based study in rural Ecuador (The Atahualpa Project)
ConclusionsPrevalence and correlates of white matter hyperintensities in elders living in rural Ecuador is almost comparable with that reported from industrialized nations, reinforcing the concept that the burden of small vessel disease is on the rise in underserved Latin American populations.
Source: International Journal of Stroke - December 1, 2014 Category: Neurology Authors: Oscar H. Del Brutto, Robertino M. Mera, Victor J. Del Brutto, Mauricio Zambrano, Julio Lama Tags: Research Source Type: research

Stroke in rural coastal Ecuador: a community‐based survey
Stroke will be South America's next epidemic. Therefore, information on stroke particularities in the region will help to overcome its impact burden. We evaluated prevalence, pattern of sub‐types, and pathogenic mechanisms underlying stroke in Atahualpa, a village representative of rural coastal Ecuador. In a three‐phase epidemiologic study, suspected cases were detected by a door‐to‐door survey (Phase I). Then, neurologists evaluated suspected cases and randomly selected negative persons (Phase II), and confirmed patients underwent complementary exams (Phase III). We found 20 stroke patients (mean age 70 years, 60...
Source: International Journal of Stroke - August 1, 2013 Category: Neurology Authors: Oscar H. Del Brutto, Milton Santamaría, Mauricio Zambrano, Ernesto Peñaherrera, Freddy Pow‐Chon‐Long, Victor J. Del Brutto, Elio. Ochoa, Elsy Valdiviezo, Rocío Santibáñez Tags: Panorama Source Type: research

Door‐to‐door survey of cardiovascular health, stroke, and ischemic heart disease in rural coastal Ecuador – the Atahualpa Project: methodology and operational definitions
DiscussionImplementation of public health strategies directed to improve the cardiovascular health status of a given population must be based on studies evaluating specific risk factors at regional levels. Epidemiologic surveys such as the Atahualpa Project may prove cost‐effective in improving the cardiovascular health status of people living in Latin American rural villages by increasing the knowledge on the particular needs of these populations.
Source: International Journal of Stroke - March 19, 2013 Category: Neurology Authors: Oscar H. Del Brutto, Ernesto Peñaherrera, Elio Ochoa, Milton Santamaría, Mauricio Zambrano, Victor J. Del Brutto, Tags: Protocols Source Type: research