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Source: International Journal of Stroke
Condition: Disability
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Total 50 results found since Jan 2013.
Circadian sleep/wake rhythm abnormalities as a risk factor of a poststroke apathy
ConclusionThese results indicate that early poststroke alterations of sleep/wake circadian rhythms – easily evaluated by actigraphy – are associated with a higher risk of poststroke apathy at three‐months. In terms of clinical outcomes, our results provide targets for very early identification of patients at risk to develop apathy after stroke and for assessing when to start specific therapy to optimize rehabilitation efficiency.
Source: International Journal of Stroke - December 25, 2014 Category: Neurology Authors: Charlotte Cosin, Igor Sibon, Mathilde Poli, Michèle Allard, Sabrina Debruxelles, Pauline Renou, François Rouanet, Willy Mayo Tags: Research Source Type: research
Should minor stroke patients be thrombolyzed? A focused review and future directions
Stroke is a leading cause of morbidity and mortality worldwide. Up to 80% of ischemic stroke patients may initially present with minor symptoms. Minor stroke and transient ischemic attack patients are typically treated conservatively with antiplatelet agents and general vascular prevention strategies. Yet a high proportion develop recurrent stroke or progression of stroke and up to one in four of these patients are disabled or dead at follow‐up. Minor or rapidly improving symptoms are the top reasons for withholding thrombolytic therapy to time‐eligible stroke patients as they are believed to be ‘too good to treat’...
Source: International Journal of Stroke - December 25, 2014 Category: Neurology Authors: Amy Y. X. Yu, Michael D. Hill, Shelagh B. Coutts Tags: Review (invited) Source Type: research
Anemia on admission predicts short‐ and long‐term outcomes in patients with acute ischemic stroke
ConclusionAnemia is common among AIS patients and is associated with cardiovascular comorbidities. Low hemoglobin status independently predicts short and long‐term mortality.
Source: International Journal of Stroke - November 27, 2014 Category: Neurology Authors: Haralampos Milionis, Vasileios Papavasileiou, Ashraf Eskandari, Suzette D'Ambrogio‐Remillard, George Ntaios, Patrik Michel Tags: Research Source Type: research
Protective effect of grape seed and skin extract on cerebral ischemia in rat: implication of transition metals
Ischemic stroke is a leading cause of long lasting disability in humans and oxidative stress an important underlying cause. The present study aims to determine the effect of short term (seven‐days) administration of high dosage grape seed and skin extract (GSSE 2·5 g/kg) on ischemia/reperfusion (I/R) injury in a rat model of global ischemia. Ischemia was induced by occlusion of the common carotid arteries for 30 min followed by one‐hour reperfusion on control or GSSE treated animals. I/R induced a drastic oxidative stress characterized by high lipid and protein oxidation, a drop in antioxidant enzyme defenses, dis...
Source: International Journal of Stroke - November 3, 2014 Category: Neurology Authors: Kadri Safwen, Smine Selima, Elayed Mohamed, Limam Ferid, Cosette Pascal, Amri Mohamed, Aouani Ezzedine, Mokni Meherzia Tags: Research Source Type: research
World Stroke Organization Global Stroke Services Guidelines and Action Plan
Every two seconds, someone across the globe suffers a symptomatic stroke. ‘Silent’ cerebrovascular disease insidiously contributes to worldwide disability by causing cognitive impairment in the elderly. The risk of cerebrovascular disease is disproportionately higher in low to middle income countries where there may be barriers to stroke care. The last two decades have seen a major transformation in the stroke field with the emergence of evidence‐based approaches to stroke prevention, acute stroke management, and stroke recovery. The current challenge lies in implementing these interventions, particularly in regions ...
Source: International Journal of Stroke - September 23, 2014 Category: Neurology Authors: Patrice Lindsay, Karen L. Furie, Stephen M. Davis, Geoffrey A. Donnan, Bo Norrving Tags: Guidelines Source Type: research
Part II: predictors of depression after stroke and impact of depression on stroke outcome: an updated systematic review of observational studies
ConclusionsEarly identification of patients at high risk of depression after stroke, those with a history of depression and physical disability after stroke, would enable the early implementation of effective management and prevention strategies for depression. The reciprocal relationship between depression and physical disability highlights the need for interventions that reduce disability after stroke, which may in turn improve mood and overall recovery for an increasingly large number of stroke survivors.
Source: International Journal of Stroke - August 1, 2014 Category: Neurology Authors: Mansur A. Kutlubaev, Maree L. Hackett Tags: Research Source Type: research
Burden of stroke in Puerto Rico
Stroke is the fifth leading cause of death and the first cause of long‐term disability in Puerto Rico. Trained staff reviewed and independently validated the medical records of patients who had been hospitalized with possible stroke at any of the 20 largest hospitals located in Puerto Rico during 2007, 2009, and 2011. The mean age of the 5005 newly diagnosed stroke patients (51·2% female) was 70 years. At the time of hospitalization, women were 4½ years older, were less likely to be married (60·2% vs. 39·9%, P < 0·001), smoked less (5·8% vs. 13·4%, P < 0·001), and had significantly higher proportion...
Source: International Journal of Stroke - August 1, 2014 Category: Neurology Authors: J. C. Zevallos, F. Santiago, J. González, A. Rodríguez, L. Pericchi, R. Rodríguez‐Mercado, U. Nobo Tags: Panorama Source Type: research
Quality of life after surgical decompression for space‐occupying middle cerebral artery infarction: Systematic review
ConclusionsMost patients treated with surgical decompression for space‐occupying infarction have a reasonable quality of life at long‐term follow‐up and are satisfied with the treatment received. Severe depressive symptoms are uncommon.
Source: International Journal of Stroke - July 15, 2014 Category: Neurology Authors: Tessa Middelaar, Paul J. Nederkoorn, H. Bart Worp, Jan Stam, Edo Richard Tags: Research Source Type: research
Understanding long‐term unmet needs in Australian survivors of stroke
ConclusionThe extent to which long‐term needs were met was influenced by a variety of factors, particularly age, disability levels, and residential location. Changes need to be made to the way and extent to which survivors are supported following stroke.
Source: International Journal of Stroke - July 15, 2014 Category: Neurology Authors: Nadine E. Andrew, Monique Kilkenny, Rebecca Naylor, Tara Purvis, Erin Lalor, Natasha Moloczij, Dominique A. Cadilhac, Tags: Research Source Type: research
Charting cognitive and volumetric trajectories after stroke: protocol for the Cognition And Neocortical Volume After Stroke (CANVAS) study
DiscussionMagnetic resonance imaging markers of structural brain aging and performance on neuropsychological tests are powerful predictors of dementia. We need to understand the trajectory of regional brain volume change and cognitive decline in patients after stroke. This will allow future risk stratification for prognostic counseling, service planning, and early therapeutic intervention.
Source: International Journal of Stroke - June 3, 2014 Category: Neurology Authors: Amy Brodtmann, Emilio Werden, Heath Pardoe, Qi Li, Graeme Jackson, Geoffrey Donnan, Tiffany Cowie, Jennifer Bradshaw, David Darby, Toby Cumming Tags: Protocols Source Type: research
Hemicraniectomy for malignant middle cerebral artery infarction: Current status and future directions
Malignant middle cerebral artery infarction is a life‐threatening sub‐type of ischemic stroke that may only be survived at the expense of permanent disability. Decompressive hemicraniectomy is an effective surgical therapy to reduce mortality and improve functional outcome without promoting most severe disability. Evidence derives from three European randomized controlled trials in patients up to 60 years. The recently finished DEcompressive Surgery for the Treatment of malignant INfarction of the middle cerebral arterY – II trial gives now high‐level evidence for the effectiveness of decompressive hemicraniectomy ...
Source: International Journal of Stroke - April 11, 2014 Category: Neurology Authors: Hermann Neugebauer, Eric Jüttler Tags: Review Source Type: research
Renal dysfunction in stroke patients: A hospital‐based cohort study and systematic review
ConclusionOur findings suggest that renal dysfunction on admission is common and associated with poor outcomes over the first year. Further work is required to establish to what extent these associations are causal and whether treating impaired renal function improves outcomes.
Source: International Journal of Stroke - March 12, 2014 Category: Neurology Authors: Anne Rowat, Catriona Graham, Martin Dennis Tags: Systematic review Source Type: research
Translation of the ‘time is brain’ concept into clinical practice: Focus on prehospital stroke management
Acute stroke is one of the main causes of death and chronic disability. Thrombolysis with recombinant tissue plasminogen activator within the first hours after onset of symptoms is an effective therapeutic option for ischemic stroke. However, fewer than 2% to 7% of patients receive this treatment, primarily because most patients reach the hospital too late for the initiation of successful therapy. Several measures can reduce detrimental delay until treatment. It is of importance to use continual public awareness campaigns to reduce delays in patients' alarm of emergency medical services. Further relevant measures are repet...
Source: International Journal of Stroke - March 4, 2014 Category: Neurology Authors: A. Ragoschke‐Schumm, S. Walter, A. Haass, C. Balucani, M. Lesmeister, A. Nasreldein, L. Sarlon, A. Bachhuber, T. Licina, I. Q. Grunwald, K. Fassbender Tags: Review Source Type: research
Statin treatment in patients with acute ischemic stroke
ConclusionStatin treatment may improve the outcomes in patients with acute ischemic stroke. Further studies are necessary to confirm this finding.
Source: International Journal of Stroke - March 4, 2014 Category: Neurology Authors: Mohamed Al‐Khaled, Christine Matthis, Jürgen Eggers Tags: Research Source Type: research
Salvage of the PWI/DWI mismatch up to 48 h from stroke onset leads to favorable clinical outcome
ConclusionUsing coregistered perfusion/diffusion‐weighted image criteria, mismatch persists up to 48 h post stroke. For the whole group, the proportion of mismatch salvage remains independent of time and, although the effect is small, its salvage is independently associated with improved clinical outcomes at three‐months. Larger sample sizes are needed to determine the time limit for mismatch salvage.
Source: International Journal of Stroke - February 1, 2014 Category: Neurology Authors: H. Ma, P. Wright, L. Allport, T. G. Phan, L. Churilov, J. Ly, J. A. Zavala, S. Arakawa, B. Campbell, S. M Davis, G. A. Donnan Tags: Research Source Type: research
