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ICARUSS, the Integrated Care for the Reduction of Secondary Stroke trial: rationale and design of a randomized controlled trial of a multimodal intervention to prevent recurrent stroke in patients with a recent cerebrovascular event, ACTRN = 12611000264987
ConclusionThe ICARUSS study aims to recruit and follow up patients between 2007 and 2013 and demonstrate the effectiveness of exposure to the ICARUSS model in stroke survivors to reduce recurrent stroke or vascular events and promote the implementation of best practice risk factor management at primary care level.
Source: International Journal of Stroke - April 1, 2015 Category: Neurology Authors: J. Joubert, S. M. Davis, G. J. Hankey, C. Levi, J. Olver, G. Gonzales, G. A. Donnan Tags: Protocol Source Type: research

Pharmacological treatment and prevention of cerebral small vessel disease: a review of potential interventions
Small vessel disease encompasses lacunar stroke, white matter hyperintensities, lacunes and microbleeds. It causes a quarter of all ischemic strokes, is the commonest cause of vascular dementia, and the cause is incompletely understood. Vascular prophylaxis, as appropriate for large artery disease and cardioembolism, includes antithrombotics, and blood pressure and lipid lowering; however, these strategies may not be effective for small vessel disease, or are already used routinely so precluding further detailed study. Further, intensive antiplatelet therapy is known to be hazardous in small vessel disease through enhanced...
Source: International Journal of Stroke - February 1, 2015 Category: Neurology Authors: Philip M. Bath, Joanna M. Wardlaw Tags: Review Source Type: research

Circadian sleep/wake rhythm abnormalities as a risk factor of a poststroke apathy
ConclusionThese results indicate that early poststroke alterations of sleep/wake circadian rhythms – easily evaluated by actigraphy – are associated with a higher risk of poststroke apathy at three‐months. In terms of clinical outcomes, our results provide targets for very early identification of patients at risk to develop apathy after stroke and for assessing when to start specific therapy to optimize rehabilitation efficiency.
Source: International Journal of Stroke - December 25, 2014 Category: Neurology Authors: Charlotte Cosin, Igor Sibon, Mathilde Poli, Michèle Allard, Sabrina Debruxelles, Pauline Renou, François Rouanet, Willy Mayo Tags: Research Source Type: research

Elevated platelet‐derived growth factor AB/BB is associated with a lower risk of recurrent vascular events in stroke patients
ConclusionsHigher levels of PDGF‐AB/BB were independently associated with a lower risk of recurrent vascular events in a cohort of convalescent nondisabled stroke patients. Our findings suggest that PDGF‐AB/BB may potentially serve as a prognostic marker for outcomes pos‐ stroke and, if this result is validated in larger samples, a potential therapeutic target.
Source: International Journal of Stroke - August 1, 2014 Category: Neurology Authors: Kaavya Narasimhalu, Lu Ma, Deidre Anne De Silva, Meng‐Cheong Wong, Hui‐Meng Chang, Christopher Chen Tags: Research Source Type: research

Charting cognitive and volumetric trajectories after stroke: protocol for the Cognition And Neocortical Volume After Stroke (CANVAS) study
DiscussionMagnetic resonance imaging markers of structural brain aging and performance on neuropsychological tests are powerful predictors of dementia. We need to understand the trajectory of regional brain volume change and cognitive decline in patients after stroke. This will allow future risk stratification for prognostic counseling, service planning, and early therapeutic intervention.
Source: International Journal of Stroke - June 3, 2014 Category: Neurology Authors: Amy Brodtmann, Emilio Werden, Heath Pardoe, Qi Li, Graeme Jackson, Geoffrey Donnan, Tiffany Cowie, Jennifer Bradshaw, David Darby, Toby Cumming Tags: Protocols Source Type: research

Cognitive performance after stroke – The Framingham Heart Study
ConclusionsClinical stroke is associated with subsequent poorer performance in multiple cognitive domains. This association cannot be entirely explained by the individual's cognitive function prior to stroke or by concomitant vascular risk factor levels.
Source: International Journal of Stroke - April 1, 2014 Category: Neurology Authors: Galit Weinstein, Sarah R. Preis, Alexa S. Beiser, Rhoda Au, Margaret Kelly‐Hayes, Carlos S. Kase, Philip A. Wolf, Sudha Seshadri Tags: Research Source Type: research

The Determinants of Dementia After Stroke (DEDEMAS) Study: protocol and pilot data
This study will provide insights into the mechanisms of poststroke dementia and hold the potential to identify novel diagnostic markers and targets for preventive therapies. The study is registered at http://www.clinicaltrials.gov (NCT01334749) and will be extended as a multicenter study starting 2013.
Source: International Journal of Stroke - July 9, 2013 Category: Neurology Authors: Frank A. Wollenweber, Vera Zietemann, Axel Rominger, Christian Opherk, Anna Bayer‐Karpinska, Andreas Gschwendtner, Lisa Coloma Andrews, Katharina Bürger, Marco Duering, Martin Dichgans Tags: Protocols Source Type: research

Enlarged perivascular spaces and cerebral small vessel disease
ConclusionsEnlarged perivascular spaces are associated with age, lacunar stroke subtype and white matter lesions and should be considered as another magnetic resonance imaging marker of cerebral small vessel disease. Further evaluation of enlarged perivascular spaces in studies of ageing, stroke, and dementia is needed to determine their pathophysiological importance.
Source: International Journal of Stroke - May 22, 2013 Category: Neurology Authors: Gillian M. Potter, Fergus N. Doubal, Caroline A. Jackson, Francesca M. Chappell, Cathie L. Sudlow, Martin S. Dennis, Joanna M. Wardlaw Tags: Research Source Type: research

The China Stroke Secondary Prevention Trial (CSSPT) protocol: a double‐blinded, randomized, controlled trial of combined folic acid and B vitamins for secondary prevention of stroke
DiscussionThis is the first multicenter randomized trial of secondary prevention for ischemic stroke in a Chinese population with a higher homocysteine level but without folate food fortification.
Source: International Journal of Stroke - March 12, 2013 Category: Neurology Authors: Xuedong Liu, Ming Shi, Feng Xia, Junliang Han, Zhirong Liu, Bo Wang, Fang Yang, Li Li, Songdi Wu, Ling Wang, Nan Liu, Yali Lv, Gang Zhao Tags: Protocols Source Type: research