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Case Report Snowflakes in the heart: an ultrasonic marker of severe hypercoagulability
A 58-year-old woman with metastatic breast cancer and Coombs-positive autoimmune haemolytic anaemia presented in April, 2014, after developing right arm weakness 8 hours into a long-haul flight. ECG and telemetry showed normal sinus rhythm. Brain MRI showed multiple small foci of restricted diffusion in the anterior, middle, and posterior cerebral artery territories suggestive of cardioembolic stroke, with widespread microhaemorrhages. Carotid ultrasound showed normal carotid and vertebral artery anatomy.
Source: LANCET - January 16, 2015 Category: Journals (General) Authors: Louis W Wang, John J Grygiel, John H O'Neill, Diane Fatkin, Michael P Feneley Tags: Case Report Source Type: research

Correspondence Radiotherapy for breast cancer, the TARGIT-A trial
Javant Vaidya and colleagues report an increased risk of non-breast cancer deaths with external beam radiotherapy (EBRT) compared with intraoperative radiotherapy, highlighting the difference in cardiac events in the two treatment groups. Although the log-rank statistics show a significant difference in non-breast cancer deaths in the EBRT group, these deaths included stroke, bowel ischaemia, and other events unrelated to breast irradiation. Therefore, the number of cardiac events are small, and to suggest that the risk of cardiac death differs between EBRT and intraoperative radiotherapy would be premature.
Source: LANCET - May 16, 2014 Category: Journals (General) Authors: Penny Mackenzie, Anthony Fyles, Caroline Chung Tags: Correspondence Source Type: research