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Obituary Philip Majerus
Physician and biochemist who showed small doses of aspirin reduce the risk of heart attack and stroke. Born on July 10, 1936, in Chicago, IL, USA, he died with prostate cancer on June 8, 2016, in University City, MO, USA, aged 79 years.
Source: LANCET - July 29, 2016 Category: Journals (General) Authors: Alison Snyder Tags: Obituary Source Type: research

World Report Profile: NIMHD—NIH's institute for minority health
For many Americans, health disparities are a fact of life—and death. Compared with white people, minorities are more likely to have and die from obesity, hypertension, heart attacks, cancer, stroke, and diabetes. On average, African-American people live 4 years less than do white people. The causes of these health disparities are a complex mixture of social and genetic factors, and they affect everything from the choices people make to how they interact with medical providers to how the system interacts with them.
Source: LANCET - November 6, 2015 Category: Journals (General) Authors: Carrie Arnold Tags: World Report Source Type: research

Correspondence The promise of personalised medicine
I read with great interest the Viewpoint by Victor Dzau and colleagues (May 23, p 2118)1 who suggested that personalised and precision medicine would result in identification of patients at highest risk of six high-prevalence diseases (cancer, diabetes, heart disease, hypertension, lung disease, and stroke) and lead to subsequent early prophylactic intervention. The authors also suggested that personalised medicine could lead to substantial cumulative gains (expressed using US$100 000 per quality-adjusted life-year, with a $33 billion gain at a reduced disease incidence of 10% and up to a $607 billion gain at a 50% incid...
Source: LANCET - August 21, 2015 Category: Journals (General) Authors: Claude Matuchansky Tags: Correspondence Source Type: research

Case Report Snowflakes in the heart: an ultrasonic marker of severe hypercoagulability
A 58-year-old woman with metastatic breast cancer and Coombs-positive autoimmune haemolytic anaemia presented in April, 2014, after developing right arm weakness 8 hours into a long-haul flight. ECG and telemetry showed normal sinus rhythm. Brain MRI showed multiple small foci of restricted diffusion in the anterior, middle, and posterior cerebral artery territories suggestive of cardioembolic stroke, with widespread microhaemorrhages. Carotid ultrasound showed normal carotid and vertebral artery anatomy.
Source: LANCET - January 16, 2015 Category: Journals (General) Authors: Louis W Wang, John J Grygiel, John H O'Neill, Diane Fatkin, Michael P Feneley Tags: Case Report Source Type: research

Correspondence Radiotherapy for breast cancer, the TARGIT-A trial
Javant Vaidya and colleagues report an increased risk of non-breast cancer deaths with external beam radiotherapy (EBRT) compared with intraoperative radiotherapy, highlighting the difference in cardiac events in the two treatment groups. Although the log-rank statistics show a significant difference in non-breast cancer deaths in the EBRT group, these deaths included stroke, bowel ischaemia, and other events unrelated to breast irradiation. Therefore, the number of cardiac events are small, and to suggest that the risk of cardiac death differs between EBRT and intraoperative radiotherapy would be premature.
Source: LANCET - May 16, 2014 Category: Journals (General) Authors: Penny Mackenzie, Anthony Fyles, Caroline Chung Tags: Correspondence Source Type: research