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Source: Heart
Condition: Stroke

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Total 260 results found since Jan 2013.

Stroke prevention for patients with atrial fibrillation: improving but not perfect yet
Atrial fibrillation (AF) is the most common cardiac rhythm disorder1 and one of the most important risk factors for stroke, particularly in the elderly. Stroke-related AF is associated with significant morbidity, mortality and healthcare costs.2 Although we have abundant evidence from randomised trials that anticoagulation, and to a lesser extent antiplatelet therapy, is highly efficacious in preventing stroke in patients with AF, these therapies remain underused, especially in older patients. With an ageing population and an AF prevalence that is rapidly rising,1 a better understanding of the stroke prevention practices i...
Source: Heart - July 19, 2013 Category: Cardiology Authors: Sandhu, R. K., McAlister, F. A. Tags: Health policy, Drugs: cardiovascular system, Epidemiology Editorials Source Type: research

Comparing the decline in coronary heart disease and stroke mortality in neighbouring countries with different healthcare systems
Conclusions While differences in the pace of change in mortality were observed at different time points, similar, substantial decreases in CHD and stroke mortality were achieved between 1985 and 1989 and between 2006 and 2010 in the ROI and NI despite important differences in health service structures. There is evidence of a levelling in mortality rates in some groups in recent years.
Source: Heart - July 19, 2013 Category: Cardiology Authors: Bennett, K., Hughes, J., Jennings, S., Kee, F., Shelley, E. Tags: Drugs: cardiovascular system, Epidemiology Source Type: research

Ethnicity and stroke risk in patients with atrial fibrillation
Conclusions Despite a reduced prevalence of AF among South Asian patients, their risk of stroke is higher than for white patients or black African/Caribbean patients in association with diabetes, cardiovascular disease, and hypertension. Under-prescription of anticoagulation persists in all ethnic groups, a deficit most pronounced in the elderly. Use of the CHA2DS2VASc score would enhance optimal management in primary care.
Source: Heart - July 5, 2013 Category: Cardiology Authors: Mathur, R., Pollara, E., Hull, S., Schofield, P., Ashworth, M., Robson, J. Tags: Drugs: cardiovascular system, Hypertension, Epidemiology Heart rhythm disorders Source Type: research

Alcohol intake and prognosis of atrial fibrillation
Conclusions High alcohol intake predicts thromboembolism or death, even after adjustment for established clinical risk factors, and may help identify high risk AF patients who could be targeted for stroke and cardiovascular prevention strategies.
Source: Heart - July 5, 2013 Category: Cardiology Authors: Overvad, T. F., Rasmussen, L. H., Skjoth, F., Overvad, K., Albertsen, I. E., Lane, D. A., Lip, G. Y. H., Larsen, T. B. Tags: Editor's choice, Drugs: cardiovascular system, Epidemiology Heart rhythm disorders Source Type: research

The 10 'Best Buys' to combat heart disease, diabetes and stroke in Africa
The Economist has branded Africa as ‘the world's fastest growing continent’.1 The economy in many African countries is growing at a rate that is higher than that of European countries. HIV infection is coming under control and life expectancy is increasing as a result of widespread use of antiretroviral therapy.2 The rising economic prosperity and improving health status has been associated with what can be described as a renaissance in cardiovascular medicine that is characterised by the revival of pan-African professional organisations, such as the Pan African Society of Cardiology (PASCAR) and the creation o...
Source: Heart - June 26, 2013 Category: Cardiology Authors: Mayosi, B. M. Tags: Drugs: cardiovascular system, Hypertension, Acute coronary syndromes, Epidemiology Editorials Source Type: research

CHADS2 and CHA2DS2-VASc score to assess risk of stroke and death in patients paced for sick sinus syndrome
Conclusions CHADS2 and CHA2DS2-VASc score are associated with increased risk of stroke and death in patients paced for SSS irrespective of the presence of AF.
Source: Heart - May 13, 2013 Category: Cardiology Authors: Svendsen, J. H., Nielsen, J. C., Darkner, S., Jensen, G. V. H., Mortensen, L. S., Andersen, H. R., on behalf of the DANPACE Investigators Tags: Open access, Drugs: cardiovascular system, Epidemiology Clinical trials Source Type: research

Bilateral internal mammary artery bypass grafting: long-term clinical benefits in a series of 1000 patients
Conclusions Our longitudinal analysis presents encouraging data concerning operative risk of BIMA grafting and provides excellent long-term survival in appropriately selected patients.
Source: Heart - May 13, 2013 Category: Cardiology Authors: Popovic, B., Voillot, D., Maureira, P., Vanhuyse, F., Agrinier, N., Aliot, E., Folliguet, T., Villemot, J. P. Tags: Drugs: cardiovascular system, Interventional cardiology, Acute coronary syndromes, Epidemiology Cardiovascular surgery Source Type: research

Development and validation of a prediction rule for recurrent vascular events based on a cohort study of patients with arterial disease: the SMART risk score
Conclusions Patients at high risk for recurrent vascular events can be identified based on readily available clinical characteristics.
Source: Heart - May 13, 2013 Category: Cardiology Authors: Dorresteijn, J. A. N., Visseren, F. L. J., Wassink, A. M. J., Gondrie, M. J. A., Steyerberg, E. W., Ridker, P. M., Cook, N. R., van der Graaf, Y., on behalf of the SMART Study Group, Algra, Grobbee, Rutten, Moll, Kappelle, Mali, Doevendans Tags: Drugs: cardiovascular system, Hypertension, Acute coronary syndromes, Clinical diagnostic tests, Epidemiology, Tobacco use Prognosis research Source Type: research

The role of uric acid in the pathogenesis of human cardiovascular disease
Hyperuricaemia is common in subjects with cardiovascular disease, but is not commonly considered a true risk factor. Recent studies suggest that uric acid is biologically active and can stimulate oxidative stress, endothelial dysfunction, inflammation and vasoconstriction. Epidemiological studies have found that uric acid can independently predict the development of hypertension, as well as stroke and heart failure. Experimentally raising uric acid in animals increases blood pressure, and pilot studies suggest that lowering uric acid in humans can reduce blood pressure in hypertensive individuals. Uric acid may also have e...
Source: Heart - May 1, 2013 Category: Cardiology Authors: Kanbay, M., Segal, M., Afsar, B., Kang, D.-H., Rodriguez-Iturbe, B., Johnson, R. J. Tags: Reviews Source Type: research

Incidence, cardiovascular complications and mortality of hypertension by sex and ethnicity
Conclusions South Asian patients had higher rates of hypertension compared to the other ethnic groups. South Asian and Chinese patients had a lower risk of death and developing cardiovascular outcomes compared to whites. Women with hypertension have a better prognosis than men regardless of ethnicity.
Source: Heart - April 18, 2013 Category: Cardiology Authors: Quan, H., Chen, G., Walker, R. L., Wielgosz, A., Dai, S., Tu, K., Campbell, N. R. C., Hemmelgarn, B. R., Hill, M. D., Johansen, H., McAlister, F. A., Khan, N., for Hypertension Outcome and Surveillance Team Tags: Hypertension, Editor's choice, Drugs: cardiovascular system, Hypertension, Acute coronary syndromes, Epidemiology Source Type: research

Cardiovascular disease risk scores in identifying future frailty: the Whitehall II prospective cohort study
Conclusions The use of CVD risk scores in clinical practice may also have utility for frailty prediction.
Source: Heart - April 18, 2013 Category: Cardiology Authors: Bouillon, K., Batty, G. D., Hamer, M., Sabia, S., Shipley, M. J., Britton, A., Singh-Manoux, A., Kivimaki, M. Tags: Open access, Drugs: cardiovascular system, Epidemiology Source Type: research

Methods of accelerated atherosclerosis in diabetic patients
This article will focus on the effect of diabetes on the initiation and progression of arterial occlusive disease, preceded by a short outline of the enormous impact of this issue from a societal-economic perspective. Diabetes, a major healthcare issue The prevalence and associated costs of diabetes are expected to increase significantly. There are currently over 240...
Source: Heart - April 18, 2013 Category: Cardiology Authors: Pasterkamp, G. Tags: Diabetic heart disease, Health policy, Education in Heart, Drugs: cardiovascular system, Hypertension, Acute coronary syndromes, Stable coronary heart disease, Epidemiology, Diabetes, Metabolic disorders Source Type: research

Blood pressure targets in patients with coronary artery disease: observations from traditional and Bayesian random effects meta-analysis of randomised trials
Conclusions The present body of evidence suggests that in patients with CAD, intensive systolic BP control to ≤135 mm Hg and possibly to ≤130 mm Hg is associated with a modest reduction in stroke and heart failure but at the expense of hypotension. Lower was better, although not consistently so for myocardial infarction, stroke, heart failure and perhaps angina. Further trials are needed to prove these findings.
Source: Heart - April 5, 2013 Category: Cardiology Authors: Bangalore, S., Kumar, S., Volodarskiy, A., Messerli, F. H. Tags: Drugs: cardiovascular system, Hypertension, Acute coronary syndromes, Stable coronary heart disease, Epidemiology Systematic review Source Type: research

Risk assessment in hypertrophic cardiomyopathy: contemporary guidelines hampered by insufficient evidence
If it were not for the great variability among individuals, medicine might as well be a science and not an art. (Sir William Osler, 1892) The sudden unexpected death of an individual at any age has a profound effect on the family and the wider community and this is particularly significant when it affects a young person. Hypertrophic cardiomyopathy remains one of the common causes of sudden cardiac death (SCD) in young individuals.1 In a cohort of 744 patients with hypertrophic cardiomyopathy from the USA and Italy, where 86 (12%) died over an 8 (SD±7) year period of follow-up, three main modes of death were identif...
Source: Heart - March 19, 2013 Category: Cardiology Authors: McKeown, P. P., Muir, A. R. Tags: Open access, Hypertrophic cardiomyopathy, Drugs: cardiovascular system, Hypertension Editorials Source Type: research

Is C reactive protein expression affected by local microenvironment?
The role that inflammation plays on the vasculature has become fundamental in our understanding of the different steps underlying the development of coronary heart disease (CHD).1 Immunological-related inflammatory processes accompany all stages of atherosclerosis development, from the early formation of lesions in the arteries to the rupture of the atherosclerotic plaques, which leads to dramatic consequences such as myocardial infarction and stroke. In this light, the search of markers of inflammation that could help to predict and even to treat cardiovascular diseases has been the subject of intense investigation. C rea...
Source: Heart - March 19, 2013 Category: Cardiology Authors: Ummarino, D., Zeng, L. Tags: Drugs: cardiovascular system, Acute coronary syndromes, Epidemiology Editorials Source Type: research