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Source: Heart
Condition: Hypertension

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Total 72 results found since Jan 2013.

Two (or more) sides of a coin
There has been a lot of controversy concerning the prognostic role of obesity on cardiovascular morbidity and mortality. Several studies with cardiovascular patients (heart failure, coronary, cerebrovascular and peripheral artery diseases, hypertension and atrial fibrillation) have reported better or similar risk of cardiovascular events and mortality among overweight and obese individuals as compared to lean ones.1 Since obesity is an independent risk factor for cardiovascular diseases, these findings initially surprised researchers, who coined the term ‘obesity paradox’. The increasingly debated ‘metabo...
Source: Heart - August 21, 2014 Category: Cardiology Authors: Beleigoli, A., Diniz, M. d. F. Tags: Drugs: cardiovascular system, Hypertension, Acute coronary syndromes, Epidemiology Editorials Source Type: research

Increased risk of coronary heart disease in patients with chronic osteomyelitis: a population-based study in a cohort of 23 million
Conclusions This study demonstrates that COM is an independent risk factor for CHD, particularly in the younger population. Further studies are necessary to explore the underlying mechanisms linking COM and CHD.
Source: Heart - August 21, 2014 Category: Cardiology Authors: Hsiao, L.-C., Muo, C.-H., Chen, Y.-C., Chou, C.-Y., Tseng, C.-H., Chang, K.-C. Tags: Health policy, Drugs: cardiovascular system, Hypertension, Epidemiology, Metabolic disorders Coronary artery disease Source Type: research

Right ventricular stroke work in children with pulmonary arterial hypertension: a promising approach
To the Editor, We read with great interest the article by Di Maria et al,1 describing the importance of RV performance, especially RV stroke work (RVSW), in children with pulmonary arterial hypertension (PAH). The authors investigated the relation between echocardiographic measurements of RV function and the ‘gold standard’ of right heart catheterisation in children and found that RVSW strongly correlates with non-invasive data of RV function.1 The authors concluded that RVSW correlates with outcome parameters, for example, abnormal WHO class, and mortality, in children with PAH. We completely agree with the fi...
Source: Heart - August 6, 2014 Category: Cardiology Authors: Pansy, J., Koestenberger, M. Tags: PostScript Source Type: research

Asymptomatic adults with mild/moderate isolated native pulmonary valve stenosis are in need of treatment... but not the kind you are thinking of!
As new treatment strategies are developed which outperform previous approaches in terms of safety, efficacy and long-term results, a reappraisal of old therapeutic dogmas is warranted, including lowering the threshold for intervention. Pulmonary valvuloplasty was introduced in 1982 to treat children and adults with significant isolated pulmonary valve stenosis (PS) and provided a very reliable tool to treat the problem avoiding cardiac surgery, with very good long-term results in terms of reinterventions as well as functional outcomes.1 2 Besides the neonate with critical PS, the same technique has been used to treat older...
Source: Heart - August 6, 2014 Category: Cardiology Authors: Giardini, A., Cervi, E. Tags: Congenital heart disease, Drugs: cardiovascular system, Hypertension, Interventional cardiology, Right sided valvular heart disease Editorials Source Type: research

RV stroke work in children with pulmonary arterial hypertension: estimation based on invasive haemodynamic assessment and correlation with outcomes
Conclusions RVSW can be estimated in children with PAH, and is significantly associated with abnormal WHO class, the need for septostomy, as well as mortality. Indices accounting for RV performance as well as ventricular-vascular coupling may be useful in the prognosis and, hence, management of children with PAH.
Source: Heart - August 6, 2014 Category: Cardiology Authors: Di Maria, M. V., Younoszai, A. K., Mertens, L., Landeck, B. F., Ivy, D. D., Hunter, K. S., Friedberg, M. K. Tags: Congenital heart disease, Drugs: cardiovascular system, Echocardiography, Hypertension, Clinical diagnostic tests, Epidemiology Pulmonary vascular disease Source Type: research

Allopurinol reduces brachial and central blood pressure, and carotid intima-media thickness progression after ischaemic stroke and transient ischaemic attack: a randomised controlled trial
Conclusions Allopurinol lowered CBP and reduced CIMT progression at 1 year compared with placebo in patients with recent ischaemic stroke and TIA. This extends the evidence of sustained beneficial effects of allopurinol to these prognostically significant outcomes and to the stroke population, highlighting the potential for reduction in cardiovascular events with this treatment strategy. Trial registration number ISRCTN11970568.
Source: Heart - June 21, 2014 Category: Cardiology Authors: Higgins, P., Walters, M. R., Murray, H. M., McArthur, K., McConnachie, A., Lees, K. R., Dawson, J. Tags: Hypertension, Epidemiology Cardiac risk factors and prevention Source Type: research

Resistant hypertension: resistance to treatment or resistance to taking treatment?
The treatment of hypertension has been a therapeutic success. A generation or more of effective drugs deserves considerable credit for their contribution to the substantial decline in age-related incidence of stroke, ischaemic heart disease and heart failure. And because almost all the drugs are long-since off patent, the cost of success comes cheaply. Indeed, National Institute of Health and Care Excellence (NICE) has branded treatment of hypertension as not only cost effective but cost saving.1 Yet not all patients achieve their blood pressure target and are labelled as ‘resistant hypertension’. A contentious...
Source: Heart - May 8, 2014 Category: Cardiology Authors: Brown, M. J. Tags: Drugs: cardiovascular system, Hypertension, Interventional cardiology, Epidemiology Editorials Source Type: research

Cardiovascular highlights from non-cardiology journals
Stenting of atherosclerotic renal artery disease fails to improve outcomes Atherosclerotic renal-artery stenosis is common among patients with cardiovascular disease and the condition may contribute to hypertension. The impact of renal artery angioplasty or stenting on the risk of clinical events among patients with atherosclerotic renal disease remains poorly defined. In the Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL) study, 947 patients atherosclerotic renal-artery stenosis and hypertension and/or chronic kidney disease were randomized to medical therapy alone or medical therapy plus renal artery ste...
Source: Heart - April 16, 2014 Category: Cardiology Authors: Bradley, S. M. Tags: Journal scan Source Type: research

Cardiac output response and peripheral oxygen extraction during exercise among symptomatic hypertrophic cardiomyopathy patients with and without left ventricular outflow tract obstruction
Conclusions Cardiac reserve is reduced in HCM because of failure of SV augmentation. LVOTO exacerbates this abnormal response, but haemodynamic responses vary significantly. Non-invasive exercise haemodynamic assessment may improve understanding of symptoms and help tailor therapy.
Source: Heart - March 21, 2014 Category: Cardiology Authors: Critoph, C. H., Patel, V., Mist, B., Elliott, P. M. Tags: Hypertrophic cardiomyopathy, Drugs: cardiovascular system, Hypertension Heart failure and cardiomyopathies Source Type: research

Effects of antihypertensive treatment in patients over 65 years of age: a meta-analysis of randomised controlled studies
Conclusion Reducing BP to a level of 150/80 mmHg is associated with large benefit in stroke, cardiovascular and all-cause mortality as well as heart failure risk in elderly individuals. Different antihypertensive regimens with equal BP reduction have similar effects on cardiovascular outcomes. SBP rather than DBP reduction is significantly related to lower cardiovascular risk in this population.
Source: Heart - January 23, 2014 Category: Cardiology Authors: Briasoulis, A., Agarwal, V., Tousoulis, D., Stefanadis, C. Tags: Drugs: cardiovascular system, Hypertension, Epidemiology Cardiac risk factors and prevention Source Type: research

Progress: the ROPAC multinational registry advances our understanding of an important outcome in pregnant women with heart disease
When caring for women with structural heart disease (SHD), clinicians face an apparent paradox: most women with SHD are able to complete a pregnancy without complication; however, compared with the general population, maternal risk is increased and SHD remains a major source of maternal morbidity and mortality and poor fetal outcomes.1–4 Identifying those women with SHD who are at increased risk for meaningful complications during pregnancy is critical. During pregnancy, intravascular volume, stroke volume, heart rate and cardiac output increase, while systemic vascular resistance decreases. During pregnancy, women w...
Source: Heart - January 3, 2014 Category: Cardiology Authors: Krieger, E. V., Stout, K. K. Tags: Congenital heart disease, Drugs: cardiovascular system, Hypertension, Acute coronary syndromes, Epidemiology Editorials Source Type: research

Global left ventricular longitudinal systolic strain as a major predictor of cardiovascular events in patients with atrial fibrillation
Conclusions GLS was a major parameter and stronger than LVEF and Sa in predicting adverse CV events and could offer an additional prognostic benefit over conventional clinical and echocardiographic systolic parameters in AF.
Source: Heart - October 6, 2013 Category: Cardiology Authors: Su, H.-M., Lin, T.-H., Hsu, P.-C., Lee, W.-H., Chu, C.-Y., Lee, C.-S., Voon, W.-C., Lai, W.-T., Sheu, S.-H. Tags: Drugs: cardiovascular system, Echocardiography, Hypertension, Clinical diagnostic tests, Epidemiology Cardiovascular imaging Source Type: research

The positive predictive value of ct-proAVP (copeptin) in patients with STEMI
Recently Reinstadler et al reported on a study in n=54 patients diagnosed with STEMI who underwent copeptin sampling 2 (1–3) days after the index event and Cardiac Magnetic Resonance (CMR) on the same day. A follow-up CMR study was done after 4 months in n=47 patients. The authors found a strong and significant correlation between day 2 copeptin and ejection fraction, end systolic volume, stroke volume and per cent infarct mass. Additionally, using optimised cutoffs, adverse remodelling could be excluded by the combination of copeptin with NT-proBNP.1 Copeptin is a stable glycopeptide comprising the C-terminal p...
Source: Heart - September 20, 2013 Category: Cardiology Authors: Mockel, M., Searle, J. Tags: Drugs: cardiovascular system, Hypertension, Interventional cardiology, Acute coronary syndromes, Clinical diagnostic tests Editorials Source Type: research

Cognitive outcomes after acute coronary syndrome: a population based comparison with transient ischaemic attack and minor stroke
Conclusions Risk of cognitive impairment after ACS is similar to minor stroke and higher than TIA with implications for clinical practice including consent and adherence with medication. Differences in cognitive domain performance suggest a greater role for degenerative brain pathology in ACS which may be linked to vascular risk profile and cardiac factors.
Source: Heart - September 20, 2013 Category: Cardiology Authors: Volonghi, I., Pendlebury, S. T., Welch, S. J. V., Mehta, Z., Rothwell, P. M. Tags: Acute coronary syndromes, Drugs: cardiovascular system, Hypertension, Epidemiology, Tobacco use Source Type: research

Almanac 2013: Novel non-coronary cardiac interventions
Recent innovations in interventional cardiology have dramatically expanded the therapeutic options for patients with cardiac conditions. Interventional cardiology is no longer limited to the treatment of coronary artery disease but allows also treatment of valvular disease, stroke prevention, hypertension, etc. One of the most important new treatment options is the percutaneous treatment for aortic valve stenosis (transcatheter aortic valve implantation), since aortic valve disease is a rather common problem in elderly patients, with many of them at high risk for surgery. Similarly, mitral regurgitation is often associated...
Source: Heart - August 15, 2013 Category: Cardiology Authors: Meier, P., Franzen, O., Lansky, A. J. Tags: Drugs: cardiovascular system, Hypertension, Interventional cardiology, Aortic valve disease, Mitral valve disease Almanac 2013 Source Type: research