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Source: European Heart Journal
Condition: Heart Failure

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Total 60 results found since Jan 2013.

Antithrombotic therapy in heart failure patients with and without atrial fibrillation: update and future challenges
Atrial fibrillation (AF) and heart failure (HF) often coexist, and patients with AF and HF have a higher risk of thromboembolic events and overall mortality compared with those with AF without HF. Additionally, the prevalence of AF increases with the severity of HF. The use of vitamin K antagonists is more unstable in patients with concomitant AF and HF, which is an independent risk factor for reduced time under therapeutic range. More recently, non-vitamin K antagonists oral anticoagulants (NOACs) have emerged as therapeutic alternatives for stroke prevention in patients with non-valvular AF, as they have been shown to be...
Source: European Heart Journal - August 23, 2016 Category: Cardiology Authors: Ferreira, J. P., Girerd, N., Alshalash, S., Konstam, M. A., Zannad, F. Tags: Clinical update Source Type: research

SOURCE 3: 1-year outcomes post-transcatheter aortic valve implantation using the latest generation of the balloon-expandable transcatheter heart valve
ConclusionIn SOURCE 3, we observe a low complication rate and mortality at 1  year. Given the low incidence of higher degree paravalvular leakages, this variable did no longer affect outcome. Clinicaltrial.gov number: NCT02698956.
Source: European Heart Journal - June 12, 2017 Category: Cardiology Source Type: research

A meta-analysis of continuous positive airway pressure therapy in prevention of cardiovascular events in patients with obstructive sleep apnoea
ConclusionCPAP therapy might reduce MACE and stroke among subjects with CPAP time exceeding 4  h/night. Additional randomized trials mandating adequate CPAP time adherence are required to confirm this impression.
Source: European Heart Journal - October 24, 2017 Category: Cardiology Source Type: research

Genetic predisposition to smoking in relation to 14 cardiovascular diseases
ConclusionThis MR study supports a causal association between smoking and a broad range of CVDs, in particular, coronary artery disease, heart failure, abdominal aortic aneurysm, ischaemic stroke, transient ischaemic attack, peripheral arterial disease, and arterial hypertension.
Source: European Heart Journal - April 16, 2020 Category: Cardiology Source Type: research

The effect of intracoronary infusion of bone marrow-derived mononuclear cells on all-cause mortality in acute myocardial infarction: the BAMI trial
Conclusions  Although BAMI is the largest trial of autologous cell-based therapy in the treatment of AMI, unexpectedly low recruitment and event rates preclude any meaningful group comparisons and interpretation of the observed results.
Source: European Heart Journal - August 30, 2020 Category: Cardiology Source Type: research

Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial
ConclusionRoutine ingestion by hypertensive patients of ≥1 prescribed BP-lowering medications at bedtime, as opposed to upon waking, results in improved ABP control (significantly enhanced decrease in asleep BP and increased sleep-time relative BP decline, i.e. BP dipping) and, most importantly, markedly diminished occurrence of major CVD events.Trial registrationClinicalTrials.gov, number NCT00741585. 
Source: European Heart Journal - October 22, 2019 Category: Cardiology Source Type: research

Low-density lipoprotein cholesterol reduction and statin intensity in myocardial infarction patients and major adverse outcomes: a Swedish nationwide cohort study
Conclusions  Larger early LDL-C reduction and more intensive statin therapy after MI were associated with a reduced hazard of all CV outcomes and all-cause mortality. This supports clinical trial data suggesting that earlier lowering of LDL-C after an MI confers the greatest benefit.
Source: European Heart Journal - December 24, 2020 Category: Cardiology Source Type: research

Vegetarians, fish, poultry, and meat-eaters: who has higher risk of cardiovascular disease incidence and mortality? A prospective study from UK Biobank
Conclusion  Eating fish rather than meat or poultry was associated with a lower risk of a range of adverse cardiovascular outcomes. Vegetarianism was only associated with a lower risk of CVD incidence.
Source: European Heart Journal - December 14, 2020 Category: Cardiology Source Type: research

Effect of antihypertensive therapy on ventricular-arterial mechanics, coupling, and efficiency
Conclusion Antihypertensive therapy reduces arterial and ventricular stiffness, enhances ventricular–arterial coupling, reduces cardiac work, and improves LV efficiency, systolic, and diastolic function. Attenuated responses in women and among obese subjects suggest that structure–function changes may be less reversible in these groups, possibly explaining their greater susceptibility to ultimately develop heart failure.
Source: European Heart Journal - March 1, 2013 Category: Cardiology Authors: Lam, C. S. P., Shah, A. M., Borlaug, B. A., Cheng, S., Verma, A., Izzo, J., Oparil, S., Aurigemma, G. P., Thomas, J. D., Pitt, B., Zile, M. R., Solomon, S. D. Tags: Hypertension Source Type: research

A new look at atrial fibrillation: lessons learned from drugs, pacing, and ablation therapies
Atrial fibrillation (AF) is the most common arrhythmia and among the leading causes of stroke and heart failure in Western populations. Despite the increasing size of clinical trials assessing the efficacy and safety of AF therapies, achieved outcomes have not always matched expectations. Considering that AF is a symptom of many possible underlying diseases, clinical research for this arrhythmia should take into account their respective pathophysiology. Accordingly, the definition of the study populations to be included should rely on the established as well as on the new classifications of AF and take advantage from a dif...
Source: European Heart Journal - September 14, 2013 Category: Cardiology Authors: Kappenberger, L. Tags: REVIEWS Source Type: research

Prognostic significance of prolonged PR interval in the general population
Conclusion In the middle-aged general population, prolonged PR interval normalizes in a substantial proportion of subjects during the time course, and it is not associated with an increased risk of all-cause or cardiovascular mortality.
Source: European Heart Journal - January 7, 2014 Category: Cardiology Authors: Aro, A. L., Anttonen, O., Kerola, T., Junttila, M. J., Tikkanen, J. T., Rissanen, H. A., Reunanen, A., Huikuri, H. V. Tags: Arrhythmia/electrophysiology Source Type: research

Improved long-term clinical outcomes in patients with ST-elevation myocardial infarction undergoing remote ischaemic conditioning as an adjunct to primary percutaneous coronary intervention
Conclusion Remote ischaemic conditioning before primary percutaneous coronary intervention seemed to improve long-term clinical outcomes in patients with ST-elevation myocardial infarction.
Source: European Heart Journal - January 14, 2014 Category: Cardiology Authors: Sloth, A. D., Schmidt, M. R., Munk, K., Kharbanda, R. K., Redington, A. N., Schmidt, M., Pedersen, L., Sorensen, H. T., Botker, H. E., CONDI Investigators Tags: FASTTRACK CLINICAL RESEARCH Source Type: research

Early diastolic strain rate in relation to systolic and diastolic function and prognosis in acute myocardial infarction: a two-dimensional speckle-tracking study
Conclusion Deformation-based E/e'sr contributes important information about global myocardial relaxation superior to velocity-based analysis and is independently associated with the outcome in acute MI.
Source: European Heart Journal - March 7, 2014 Category: Cardiology Authors: Ersboll, M., Andersen, M. J., Valeur, N., Mogensen, U. M., Fahkri, Y., Thune, J. J., Moller, J. E., Hassager, C., Sogaard, P., Kober, L. Tags: Imaging Source Type: research

Prognostic models for stable coronary artery disease based on electronic health record cohort of 102 023 patients
Conclusion These validated prognostic models could be used in clinical practice to support risk stratification as recommended in clinical guidelines.
Source: European Heart Journal - April 1, 2014 Category: Cardiology Authors: Rapsomaniki, E., Shah, A., Perel, P., Denaxas, S., George, J., Nicholas, O., Udumyan, R., Feder, G. S., Hingorani, A. D., Timmis, A., Smeeth, L., Hemingway, H. Tags: Coronary artery disease Source Type: research

Contrast-induced acute kidney injury after primary percutaneous coronary intervention: results from the HORIZONS-AMI substudy
Conclusion Contrast-induced acute kidney injury is associated with poor short- and long-term outcomes after primary percutaneous coronary intervention in STEMI.
Source: European Heart Journal - June 14, 2014 Category: Cardiology Authors: Narula, A., Mehran, R., Weisz, G., Dangas, G. D., Yu, J., Genereux, P., Nikolsky, E., Brener, S. J., Witzenbichler, B., Guagliumi, G., Clark, A. E., Fahy, M., Xu, K., Brodie, B. R., Stone, G. W. Tags: Interventional cardiology Source Type: research