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Source: Journal of the American College of Cardiology

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Total 269 results found since Jan 2013.

Omega-3 Fatty Acids for the Prevention of Recurrent Symptomatic Atrial Fibrillation: Results of the FORWARD (Randomized Trial to Assess Efficacy of PUFA for the Maintenance of Sinus Rhythm in Persistent Atrial Fibrillation) Trial
Conclusions: Pharmacological supplementation with 1 g of n-3 PUFA for 1 year did not reduce recurrent AF. (Randomized Trial to Assess Efficacy of PUFA for the Maintenance of Sinus Rhythm in Persistent Atrial Fibrillation [FORWARD]; NCT00597220)
Source: Journal of the American College of Cardiology - December 26, 2012 Category: Cardiology Authors: Alejandro Macchia, Hugo Grancelli, Sergio Varini, Daniel Nul, Nicolás Laffaye, Javier Mariani, Daniel Ferrante, Raúl Badra, Julio Figal, Silvina Ramos, Gianni Tognoni, Hernán C. Doval, GESICA Investigators Tags: Heart Rhythm Disorders in Heart Failure Source Type: research

Behavioral Mechanisms, Elevated Depressive Symptoms, and the Risk for Myocardial Infarction or Death in Individuals With Coronary Heart Disease: The REGARDS (Reason for Geographic and Racial Differences in Stroke) Study
Conclusions: Our findings suggest potential roles for behavioral interventions targeting smoking and physical inactivity in patients with CHD and comorbid depression.
Source: Journal of the American College of Cardiology - January 7, 2013 Category: Cardiology Authors: Siqin Ye, Paul Muntner, Daichi Shimbo, Suzanne E. Judd, Joshua Richman, Karina W. Davidson, Monika M. Safford Tags: Coronary Artery Disease Source Type: research

Prognostic Impact of the Presence and Absence of Angina on Mortality and Cardiovascular Outcomes in Patients With Type 2 Diabetes and Stable Coronary Artery Disease: Results from the BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) Trial
Conclusions: Whatever their symptom status, patients with type 2 diabetes and stable CAD were at similar risk of cardiovascular events and death. These findings suggest that these patients may be similarly managed in terms of risk stratification and preventive therapies. (Bypass Angioplasty Revascularization Investigation 2 Diabetes [BARI 2D]; NCT00006305)
Source: Journal of the American College of Cardiology - February 14, 2013 Category: Cardiology Authors: Gilles R. Dagenais, Jiang Lu, David P. Faxon, Peter Bogaty, Dale Adler, Francisco Fuentes, Jorge Escobedo, Ashok Krishnaswami, James Slater, Robert L. Frye, BARI 2D Study Group Tags: Coronary Artery Disease Source Type: research

The Year in Review of Clinical Cardiac Electrophysiology
This past year saw multiple important advances in the field clinical cardiac electrophysiology. Seminal articles describing new anticoagulant drugs for stroke prevention in atrial fibrillation were published. New results that raise questions regarding the safety of dronedarone and several new promising techniques in AF ablation were described. Important articles that refine our understanding of the risk of sudden death among Wolff-Parkinson-White patients were published. In the basic and translational sciences, the application of gene therapy to the study and potential treatment of arrhythmias was described, whereas geneti...
Source: Journal of the American College of Cardiology - January 14, 2013 Category: Cardiology Authors: Gregory M. Marcus, Edmund Keung, Melvin M. Scheinman Tags: YEAR IN CARDIOLOGY SERIES Source Type: research

Percutaneous Coronary Intervention Versus Coronary Bypass Surgery in United States Veterans With Diabetes
Conclusions: This study was severely underpowered for its primary endpoint, and therefore no firm conclusions about the comparative effectiveness of CABG and PCI are possible. There were interesting differences in the components of the primary endpoint. However, the confidence intervals are very large, and the findings must be viewed as hypothesis generating only. (Coronary Artery Revascularization in Diabetes; NCT00326196)
Source: Journal of the American College of Cardiology - February 20, 2013 Category: Cardiology Authors: Masoor Kamalesh, Thomas G. Sharp, X. Charlene Tang, Kendrick Shunk, Herbert B. Ward, James Walsh, Spencer King, Cindy Colling, Thomas Moritz, Kevin Stroupe, Domenic Reda, VA CARDS Investigators Tags: Interventional Cardiology Source Type: research

Transcatheter Aortic Valve Implantation With the Edwards SAPIEN Versus the Medtronic CoreValve Revalving System Devices: A Multicenter Collaborative Study: The PRAGMATIC Plus Initiative (Pooled-RotterdAm-Milano-Toulouse In Collaboration)
Objectives: The aim of this study was to compare outcomes after transfemoral transcatheter aortic valve implantation with the Medtronic CoreValve (MCV) versus the Edwards SAPIEN/SAPIEN XT transcatheter heart valve (ESV) for severe aortic stenosis. Background: No large matched comparison study has been conducted so far evaluating both commercially available devices. Methods: The data from databases of 4 experienced European centers were pooled and analyzed. Due to differences in baseline clinical characteristics, propensity score matching was performed. Study objectives were Valve Academic Research Consortium outcomes ...
Source: Journal of the American College of Cardiology - January 21, 2013 Category: Cardiology Authors: Alaide Chieffo, Gill Louise Buchanan, Nicolas M. Van Mieghem, Didier Tchetche, Nicolas Dumonteil, Azeem Latib, Robert M.A. van der Boon, Olivier Vahdat, Bertrand Marcheix, Bruno Farah, Patrick W. Serruys, Jean Fajadet, Didier Carrié, Peter P.T. de Jaeger Tags: Heart Valve Disease Source Type: research

Effect of Atrial Fibrillation on Atrial Thrombogenesis in Humans: Impact of Rate and Rhythm
Objectives: We sought to assess the effect of atrial fibrillation (AF) on atrial thrombogenesis in humans by determining the impact of rate and rhythm. Background: Although AF is known to increase the risk of thromboembolic stroke from the left atrium (LA), the exact mechanisms remain poorly understood. Methods: We studied 55 patients with AF who underwent catheter ablation while in sinus rhythm; 20 patients were induced into AF, 20 patients were atrial paced at 150 beats/min, and 15 were control patients. Blood samples were taken from the LA, right atrium, and femoral vein at baseline and at 15 min in all 3 groups. P...
Source: Journal of the American College of Cardiology - January 21, 2013 Category: Cardiology Authors: Han S. Lim, Scott R. Willoughby, Carlee Schultz, Cheryl Gan, Muayad Alasady, Dennis H. Lau, Darryl P. Leong, Anthony G. Brooks, Glenn D. Young, Peter M. Kistler, Jonathan M. Kalman, Matthew I. Worthley, Prashanthan Sanders Tags: Heart Rhythm Disorders Source Type: research

Transcatheter Aortic Valve Implantation for Pure Severe Native Aortic Valve Regurgitation
Conclusions: This registry analysis demonstrates the feasibility and potential procedure difficulties when using TAVI for severe NAVR. Acceptable results may be achieved in carefully selected patients who are deemed too high risk for conventional surgery, but the possibility of requiring 2 valves and leaving residual aortic regurgitation remain important considerations.
Source: Journal of the American College of Cardiology - February 25, 2013 Category: Cardiology Authors: David A. Roy, Ulrich Schaefer, Victor Guetta, David Hildick-Smith, Helge Möllmann, Nicholas Dumonteil, Thomas Modine, Johan Bosmans, Anna Sonia Petronio, Neil Moat, Axel Linke, Cesar Moris, Didier Champagnac, Radoslaw Parma, Andrzej Ochala, Diego Medvedo Tags: Interventional Cardiology Source Type: research

Primary Percutaneous Coronary Intervention: The Deception of Delay⁎
Primary percutaneous coronary intervention (PCI) has become the predominant reperfusion strategy for ST-segment elevation myocardial infarction (STEMI) throughout western healthcare systems. Recent estimates in the United States suggest that primary PCI is used in 85% of all STEMI cases that undergo reperfusion, with thrombolytic agents used in only 9% and the combination of thrombolytic agents with PCI in 6% (). This dramatic switch from thrombolytic therapy to primary PCI was the result of several studies conducted in the early 1990s that demonstrated the superiority of primary PCI at reducing stroke and reinfarction as ...
Source: Journal of the American College of Cardiology - April 17, 2013 Category: Cardiology Authors: Cindy L. Grines, Theodore Schreiber Tags: Acute Coronary Syndromes: Editorial Comment Source Type: research

5-Year Experience With Transcatheter Transapical Mitral Valve-in-Valve Implantation for Bioprosthetic Valve Dysfunction
Objectives: The study sought to describe the authors' experience with mitral transapical transcatheter valve-in-valve implantation (TVIV). Background: Increasing numbers of mitral biological prostheses are being implanted in clinical practice. Transcatheter valve-in-valve implantation may be a lower risk alternative treatment for high-risk patients with mitral valve degeneration. Methods: Twenty-three consecutive patients with severe mitral bioprosthetic valve dysfunction underwent transapical mitral TVIV between July 2007 and September 2012. Bioprosthetic failure was secondary to stenosis in 6 (26.1%), regurgitation ...
Source: Journal of the American College of Cardiology - April 24, 2013 Category: Cardiology Authors: Anson Cheung, John G. Webb, Marco Barbanti, Melanie Freeman, Ronald K. Binder, Christopher Thompson, David A. Wood, Jian Ye Tags: Interventional Cardiology Source Type: research

The Relationship Between Metabolic Risk Factors and Incident Cardiovascular Disease in Europeans, South Asians, and African Caribbeans: SABRE (Southall and Brent Revisited)—A Prospective Population-Based Study
This study sought to determine whether ethnic differences in diabetes, dyslipidemia, and ectopic fat deposition account for ethnic differences in incident cardiovascular disease. Background: Coronary heart disease risks are elevated in South Asians and are lower in African Caribbeans compared with Europeans. These ethnic differences map to lipid patterns and ectopic fat deposition. Methods: Cardiovascular risk factors were assessed in 2,049 Europeans, 1,517 South Asians, and 630 African Caribbeans from 1988 through 1991 (mean age: 52.4 ± 6.9 years). Fatal and nonfatal events were captured over a median 20.5-year follo...
Source: Journal of the American College of Cardiology - April 24, 2013 Category: Cardiology Authors: Therese Tillin, Alun D. Hughes, Jamil Mayet, Peter Whincup, Naveed Sattar, Nita G. Forouhi, Paul M. McKeigue, Nish Chaturvedi Tags: Cardiometabolic Risk Source Type: research

Invasive Hemodynamic Characteristics of Low Gradient Severe Aortic Stenosis Despite Preserved Ejection Fraction
Conclusions: Occurrence of low gradient severe aortic stenosis despite preserved ejection fraction was confirmed by invasive hemodynamics and was not the result of a systematic bias in the echo calculation of aortic orifice area.
Source: Journal of the American College of Cardiology - April 24, 2013 Category: Cardiology Authors: Juliane Lauten, Christian Rost, Ole A. Breithardt, Christian Seligmann, Lutz Klinghammer, Werner G. Daniel, Frank A. Flachskampf Tags: Heart Valve Disease Source Type: research

Reply
We thank Drs. Eleid and Pellikka for their insightful comments with regard to our study and for giving us the opportunity to provide more information in this regard. Paradoxical low-flow, low-gradient (PLF/LG) aortic stenosis (AS) is defined by the constellation of a low-flow state (i.e., stroke volume index ≤35 ml/m2) despite a normal left ventricular (LV) ejection fraction, a small aortic valve area (
Source: Journal of the American College of Cardiology - April 24, 2013 Category: Cardiology Authors: Marie-Annick Clavel, Jean G. Dumesnil, Romain Capoulade, Patrick Mathieu, Mario Sénéchal, Philippe Pibarot Tags: Letters to the Editor Source Type: research

Rivaroxaban in Patients Stabilized After a ST-Segment Elevation Myocardial Infarction: Results From the ATLAS ACS-2–TIMI-51 Trial (Anti-Xa Therapy to Lower Cardiovascular Events in Addition to Standard Therapy in Subjects with Acute Coronary Syndrome–Thrombolysis In Myocardial Infarction-51)
Objectives: The present analysis reports on the pre-specified subgroup of ST-elevation myocardial infarction (STEMI) patients, in whom anticoagulant therapy has been of particular interest. Background: In ATLAS ACS-2–TIMI-51 (Anti-Xa Therapy to Lower Cardiovascular Events in Addition to Standard Therapy in Subjects with Acute Coronary Syndrome–Thrombolysis In Myocardial Infarction-51), rivaroxaban reduced cardiovascular events across the spectrum of acute coronary syndrome (ACS). Methods: Seven thousand eight hundred seventeen patients in ATLAS ACS-2-TIMI 51 presented with a STEMI. After being stabilized (1 to 7 d...
Source: Journal of the American College of Cardiology - May 1, 2013 Category: Cardiology Authors: Jessica L. Mega, Eugene Braunwald, Sabina A. Murphy, Alexei N. Plotnikov, Paul Burton, Robert Gabor Kiss, Alexander Parkhomenko, Michal Tendera, Petr Widimsky, C. Michael Gibson Tags: Coronary Artery Disease Source Type: research

Functional Improvement After Ventricular Assist Device Implantation: Is Ventricular Recovery More Common Than We Thought?⁎
He who's down one day can be up the next, unless he really wants to stay in bed, that is … —Miguel de Cervantes Saavedra, Don Quixote () Of the roughly 5.8 million Americans with heart failure, approximately 10% will have Stage D heart failure, defined as symptoms at rest despite optimal medical therapy. American College of Cardiology/American Heart Association and European Society of Cardiology guidelines recommend 3 options for these patients: 1) a ventricular assist device (VAD); 2) a heart transplant; or 3) hospice care (). Unfortunately, advanced therapies such as transplant and VAD are associated with significan...
Source: Journal of the American College of Cardiology - March 11, 2013 Category: Cardiology Authors: Eric Adler, Jorge Silva Enciso Tags: Heart Failure: Editorial Comment Source Type: research