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Source: Journal of the American College of Cardiology
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Total 269 results found since Jan 2013.
Tracking Body Mass Index From Childhood to Adulthood for Subclinical Cardiovascular Diseases at Adulthood
Subclinical cardiovascular diseases (CVDs), including arterial stiffness measured with carotid-femoral pulse wave velocity (cfPWV), carotid atherosclerosis measured with carotid artery intima-media thickness (cIMT), and left ventricular hypertrophy measured with left ventricular mass index (LVMI), may serve as the surrogate indexes of CVD (mainly coronary heart diseases and stroke). Previous studies have examined the relationship between childhood body mass index (BMI) and adult CVD risk, as well as subclinical CVD (1,2). However, the effect of BMI change from childhood to adulthood has not been clearly established. Moreo...
Source: Journal of the American College of Cardiology - February 23, 2016 Category: Cardiology Source Type: research
Acute Pulmonary Embolism With an Emphasis on an Interventional Approach
Compared with recent advances in treatment of serious cardiovascular diseases, such as myocardial infarction and stroke, the treatment and outcome of acute pulmonary embolism (PE) have remained relatively unchanged over the last few decades. This has prompted several experts to call for the formation of multidisciplinary PE response teams with a more proactive approach to the treatment of PE. In the current document, we discuss the formation of such teams and describe the available treatment options beyond anticoagulation, with a focus on the interventional approach. Acknowledging the paucity of data to support widespread ...
Source: Journal of the American College of Cardiology - February 23, 2016 Category: Cardiology Source Type: research
Subclinical Cardiovascular Disease and Death, Dementia, and Coronary Heart Disease in Patients 80+ Years
ConclusionsIn subjects 80+ years of age, there is a greater incidence of dementia than of CHD. CAC, as a marker of atherosclerosis, is a determinant of mortality, and risk of CHD and myocardial infarction. White women with low CAC scores had a significantly decreased risk of dementia. A very important unanswered question, especially in the very elderly, is whether prevention of atherosclerosis and its complications is associated with less Alzheimer disease pathology and dementia. (Cardiovascular Health Study [CHS]; NCT00005133)
Source: Journal of the American College of Cardiology - March 1, 2016 Category: Cardiology Source Type: research
Coronary Artery Calcification A Canary in the Cognitive Coalmine ∗
In this cognitive study cohort from the Cardiovascular Health Study (CHS) in this issue of the Journal, Kuller et al. (1) examine coronary artery calcification (CAC), a measure of subclinical cardiovascular disease, as a predictor of incident dementia and coronary events among individuals without a baseline history of clinical cardiovascular events who were predominantly 80+ years of age. The study extends previous findings by examining dementia incidence prospectively over a longer follow-up duration. The results suggest that for people who live into their 8th decade without a cardiovascular event, dementia is a more like...
Source: Journal of the American College of Cardiology - March 1, 2016 Category: Cardiology Source Type: research
Perioperative Cardiovascular Risk of Prior Coronary Stent Implantation Among Patients Undergoing Noncardiac Surgery
ConclusionsThis study found that prior coronary stent implantation is an independent risk factor for MACCE and bleeding when time from stenting to NCS is
Source: Journal of the American College of Cardiology - March 1, 2016 Category: Cardiology Source Type: research
Initial Experience With Commercial Transcatheter Mitral Valve Repair in the United States
ConclusionsIn this study of the initial commercial U.S. experience, it was found that procedural success was achieved in approximately 91% of patients, and the majority of patients were discharged home with moderate or less MR. These data support the effectiveness of this therapy in appropriately selected high-risk patients in a commercial setting. Further study is required to determine the long-term impact of transcatheter MV repair in this patient population.
Source: Journal of the American College of Cardiology - March 7, 2016 Category: Cardiology Source Type: research
Peripheral Artery Disease Evolving Role of Exercise, Medical Therapy, and Endovascular Options
The prevalence of peripheral artery disease (PAD) continues to increase worldwide. It is important to identify patients with PAD because of the increased risk of myocardial infarction, stroke, and cardiovascular death and impaired quality of life because of a profound limitation in exercise performance and the potential to develop critical limb ischemia. Despite effective therapies to lower the cardiovascular risk and prevent progression to critical limb ischemia, patients with PAD continue to be under-recognized and undertreated. The management of PAD patients should include an exercise program, guideline-based medical th...
Source: Journal of the American College of Cardiology - March 15, 2016 Category: Cardiology Source Type: research
Histamine H 2 Receptor Antagonists, Left Ventricular Morphology, and Heart Failure Risk The MESA Study
This study sought to determine whether H2RA use is associated with incident HF and change in LV morphology over time.MethodsWe included 6,378 men and women from MESA (Multi-Ethnic Study of Atherosclerosis), a multicenter prospective observational cohort of participants without cardiovascular disease at baseline. Cox proportional hazards were used to estimate the association between H2RA use and incident HF in adjusted models. In participants with cardiac magnetic resonance imaging, associations between H2RA use, baseline LV morphology (n = 4,691), and longitudinal change in the LV (n = 2,806) were estimated using linear ...
Source: Journal of the American College of Cardiology - March 29, 2016 Category: Cardiology Source Type: research
Proton-Pump Inhibitors Reduce Gastrointestinal Events Regardless of Aspirin Dose in Patients Requiring Dual Antiplatelet Therapy
ConclusionsGastroprotection with PPI therapy should be utilized in appropriately selected patients with coronary artery disease requiring DAPT, even if the patients are on low-dose aspirin. (Clopidogrel and the Optimization of Gastrointestinal Events Trial [COGENT]; NCT00557921)
Source: Journal of the American College of Cardiology - April 4, 2016 Category: Cardiology Source Type: research
Antihypertensive Drug Usage in Prediction of Incident Atrial Fibrillation A Factor Not to Be Disregarded
The Dutch PREVEND (Prevention of Renal and Vascular End-Stage Disease) cohort study (1) reported both the risk factors for atrial fibrillation (AF) and the association of AF with cardiovascular events, heart failure, and all-cause mortality. At a mean 9.7 years of follow-up of more than 8,000 middle-aged men and women, 265 cases of AF were confirmed. A greater focus was given to associations with outcome than to determinants of AF, perhaps because no unexpected factors were perceived by the investigators to emerge. However, one of the main reported findings was related to the use of antihypertensive drugs. Age- and sex-adj...
Source: Journal of the American College of Cardiology - April 4, 2016 Category: Cardiology Source Type: research
Validation of BARC Bleeding Criteria in Patients With Acute Coronary Syndromes The TRACER Trial
This study sought to investigate the relationship between BARC-classified bleeding and mortality and compared its prognostic value against 2 validated bleeding scales: TIMI (Thrombolysis In Myocardial Infarction) and GUSTO (Global Use of Strategies to Open Occluded Arteries).MethodsWe analyzed bleeding in 12,944 patients with acute coronary syndromes without ST-segment elevation, with or without early invasive strategy. The main outcome measure was all-cause death.ResultsDuring follow-up (median: 502 days), noncoronary artery bypass graft (CABG) bleeding occurred in 1,998 (15.4%) patients according to BARC (grades 2, 3, or...
Source: Journal of the American College of Cardiology - May 3, 2016 Category: Cardiology Source Type: research
Reply Considerations When Evaluating Cost-Effectiveness Analyses of Novel Stroke Prevention Therapies
We appreciate the thorough review of our paper (1) by Drs. Singh and Wijeysundera and wish to clarify our analysis based upon their feedback.
Source: Journal of the American College of Cardiology - May 3, 2016 Category: Cardiology Source Type: research
Recent Diabetes and Atrial Fibrillation Report Diverges From Pre-Existing Evidence
We read with interest the study by Ashburner et al. (1), investigating associations between duration of diabetes, glycemic control, and risk of ischemic stroke in patients with atrial fibrillation (AF) in the ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) cohort.
Source: Journal of the American College of Cardiology - May 10, 2016 Category: Cardiology Source Type: research
Reply Recent Diabetes and Atrial Fibrillation Report Diverges From Pre-Existing Evidence
We are delighted to recognize the thoughtful work by Overvad et al. (1) and Saliba et al. (2). The association of diabetes and ischemic stroke risk in patients with atrial fibrillation (AF) was first observed more than 20 years ago (3). Yet, there is scant published data analyzing this association by the core epidemiological components of diabetes duration and glycemic control.
Source: Journal of the American College of Cardiology - May 10, 2016 Category: Cardiology Source Type: research
Beyond Coronary Calcification, Family History, and C-Reactive Protein Cholesterol Efflux Capacity and Cardiovascular Risk Prediction
ConclusionsCEC improves ASCVD risk prediction beyond using CAC, FH, and hs-CRP and warrants consideration as a novel ASCVD risk marker.
Source: Journal of the American College of Cardiology - May 24, 2016 Category: Cardiology Source Type: research
