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Beyond Coronary Calcification, Family History, and C-Reactive Protein Cholesterol Efflux Capacity and Cardiovascular Risk Prediction
ConclusionsCEC improves ASCVD risk prediction beyond using CAC, FH, and hs-CRP and warrants consideration as a novel ASCVD risk marker.
Source: Journal of the American College of Cardiology - May 24, 2016 Category: Cardiology Source Type: research

Subclinical Cardiovascular Disease and Death, Dementia, and Coronary Heart Disease in Patients 80+ Years
ConclusionsIn subjects 80+ years of age, there is a greater incidence of dementia than of CHD. CAC, as a marker of atherosclerosis, is a determinant of mortality, and risk of CHD and myocardial infarction. White women with low CAC scores had a significantly decreased risk of dementia. A very important unanswered question, especially in the very elderly, is whether prevention of atherosclerosis and its complications is associated with less Alzheimer disease pathology and dementia. (Cardiovascular Health Study [CHS]; NCT00005133)
Source: Journal of the American College of Cardiology - March 1, 2016 Category: Cardiology Source Type: research

Utility of Nontraditional Risk Markers in Atherosclerotic Cardiovascular Disease Risk Assessment
ConclusionsCAC score, ABI, and FH were independent predictors of ASCVD events. CAC score modestly improved the discriminative ability of the cPCE compared with other nontraditional risk markers.
Source: Journal of the American College of Cardiology - January 12, 2016 Category: Cardiology Source Type: research

Coronary Calcium Score and the New Guidelines Back to Square One? ∗
Previous guidelines for cardiovascular risk assessment recommended the use of a modified Framingham score to estimate the 10-year risk of hard coronary heart disease (CHD) events, defined as myocardial infarction and CHD death (1). Coronary artery calcium (CAC) scoring for refined stratification received Class IIa or IIb recommendations for those at intermediate (10% to 20%) or low to intermediate (6% to 10%) risk, respectively (2). In 2013, the American College of Cardiology (ACC) and American Heart Association (AHA) released guidelines (3,4) endorsing new sex- and race-specific predictive equations derived from 5 large p...
Source: Journal of the American College of Cardiology - October 5, 2015 Category: Cardiology Source Type: research

Affinity Proteomics for Phosphatase Interactions in Atrial Fibrillation ∗
Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice, with an estimated 30 million individuals affected worldwide (1). AF constitutes a major risk factor for stroke and heart failure, resulting in significant morbidity and mortality. Remodeling of the atria is a consequence as well as a substrate for perpetuation of AF. The remodeling process occurs at various levels, including atrial fibrosis, cardiomyocyte contractibility, and electrical coupling. During electrical remodeling, an unbalanced calcium (Ca2+) transport exposes cardiomyocytes locally to increased Ca2+ levels. Ca2+ overload i...
Source: Journal of the American College of Cardiology - January 12, 2015 Category: Cardiology Source Type: research

“De-Risking” Risk Reduction: Should Coronary Artery Calcium Scoring Be the Gatekeeper to Preventive Pharmacotherapy With the Polypill?∗
The cardiovascular disease (CVD) epidemic remains the leading cause of death worldwide . Widespread adoption of the Western diet and lifestyle by populations in emergent countries with low or middle income has resulted in dramatic increases in the incidence of coronary heart disease and stroke. An overwhelming proportion of the cardiovascular risk is explained by the cumulative presence of classic and potentially modifiable risk factors, and this effect does not seem to be influenced by sex, ethnicity, or geography . Therefore, to effectively reduce risk and improve outcomes, prevention strategies should be conducted and i...
Source: Journal of the American College of Cardiology - October 25, 2013 Category: Cardiology Authors: William Wijns, Dan Rusinaru Tags: Cardiometabolic Risk: Editorial Comment Source Type: research