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Source: Journal of the American College of Cardiology
Condition: Coronary Heart Disease
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Total 20 results found since Jan 2013.
Reduction in Ischemic Events With Ticagrelor in Diabetic Patients With Prior Myocardial Infarction in PEGASUS–TIMI 54
ConclusionsIn patients with diabetes with prior MI, adding ticagrelor to aspirin significantly reduces the risk of recurrent ischemic events, including cardiovascular and coronary heart disease death. (Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin [PEGASUS]; NCT01225562)
Source: Journal of the American College of Cardiology - June 7, 2016 Category: Cardiology Source Type: research
Subclinical Cardiovascular Disease and Death, Dementia, and Coronary Heart Disease in Patients 80+ Years
ConclusionsIn subjects 80+ years of age, there is a greater incidence of dementia than of CHD. CAC, as a marker of atherosclerosis, is a determinant of mortality, and risk of CHD and myocardial infarction. White women with low CAC scores had a significantly decreased risk of dementia. A very important unanswered question, especially in the very elderly, is whether prevention of atherosclerosis and its complications is associated with less Alzheimer disease pathology and dementia. (Cardiovascular Health Study [CHS]; NCT00005133)
Source: Journal of the American College of Cardiology - March 1, 2016 Category: Cardiology Source Type: research
Tracking Body Mass Index From Childhood to Adulthood for Subclinical Cardiovascular Diseases at Adulthood
Subclinical cardiovascular diseases (CVDs), including arterial stiffness measured with carotid-femoral pulse wave velocity (cfPWV), carotid atherosclerosis measured with carotid artery intima-media thickness (cIMT), and left ventricular hypertrophy measured with left ventricular mass index (LVMI), may serve as the surrogate indexes of CVD (mainly coronary heart diseases and stroke). Previous studies have examined the relationship between childhood body mass index (BMI) and adult CVD risk, as well as subclinical CVD (1,2). However, the effect of BMI change from childhood to adulthood has not been clearly established. Moreo...
Source: Journal of the American College of Cardiology - February 23, 2016 Category: Cardiology Source Type: research
Selecting Patients for Statin Therapy in Primary Prevention If We Could Only Predict the Future ∗
Statins are effective in the primary and secondary prevention of coronary heart disease and stroke. Although many would agree that primary prevention of atherosclerotic cardiovascular disease (ASCVD) is preferable to secondary prevention, no consensus exists on how to best identify individuals at risk for the disease, when to commence screening and risk assessment, at what age to start (or stop) treatment, how to treat, and how intensively to treat. The 2013 American College of Cardiology/American Heart Association (ACC/AHA) cholesterol guidelines concluded that net benefit was sufficient to recommend statin treatment for ...
Source: Journal of the American College of Cardiology - December 14, 2015 Category: Cardiology Source Type: research
Carotid Stiffness Is Associated With Incident Stroke A Systematic Review and Individual Participant Data Meta-Analysis
ConclusionsCarotid stiffness is associated with incident stroke independently of CV factors and aortic stiffness. In addition, carotid stiffness improves stroke risk prediction beyond Framingham and aortic stiffness.
Source: Journal of the American College of Cardiology - November 2, 2015 Category: Cardiology Source Type: research
Treatment of Dyslipidemia in Elderly Patients With Coronary Heart Disease There Are Miles to Go Before We Sleep ∗
The treatment of dyslipidemia with statin therapy is a cornerstone in the management of patients in both the primary and secondary prevention settings. Dyslipidemia is widely prevalent in its various forms (1). The lowering of low-density lipoprotein cholesterol (LDL-C) with a statin in patients with established coronary heart disease (CHD) has shown unequivocal capacity to safely reduce risk for clinical sequelae such as nonfatal myocardial infarction, ischemic stroke, cardiovascular and all-cause mortality, as well as the need for revascularization (2,3). The American College of Cardiology/American Heart Association Guid...
Source: Journal of the American College of Cardiology - October 19, 2015 Category: Cardiology Source Type: research
Next Steps in Primary Prevention of Coronary Heart Disease Rationale for and Design of the ECAD Trial
Atherosclerotic cardiovascular disease (ASCVD) events, including coronary heart disease and stroke, are the most frequent cause of death and major disability in the world. Current American College of Cardiology/American Heart Association primary prevention guidelines are mainly on the basis of randomized controlled trials of statin-based low-density lipoprotein cholesterol (LDL-C)–lowering therapy for primary prevention of ASCVD events. Despite the clear demonstration of statin-based LDL-C lowering, substantial 10-year and lifetime risks of incident ASCVD continue. Although the 10-year risk is low in young and middle-age...
Source: Journal of the American College of Cardiology - October 12, 2015 Category: Cardiology Source Type: research
Coronary Calcium Score and the New Guidelines Back to Square One? ∗
Previous guidelines for cardiovascular risk assessment recommended the use of a modified Framingham score to estimate the 10-year risk of hard coronary heart disease (CHD) events, defined as myocardial infarction and CHD death (1). Coronary artery calcium (CAC) scoring for refined stratification received Class IIa or IIb recommendations for those at intermediate (10% to 20%) or low to intermediate (6% to 10%) risk, respectively (2). In 2013, the American College of Cardiology (ACC) and American Heart Association (AHA) released guidelines (3,4) endorsing new sex- and race-specific predictive equations derived from 5 large p...
Source: Journal of the American College of Cardiology - October 5, 2015 Category: Cardiology Source Type: research
Orthostatic Hypotension Epidemiology, Prognosis, and Treatment
Orthostatic hypotension (OH) is a common cardiovascular disorder, with or without signs of underlying neurodegenerative disease. OH is diagnosed on the basis of an orthostatic challenge and implies a persistent systolic/diastolic blood pressure decrease of at least 20/10 mm Hg upon standing. Its prevalence is age dependent, ranging from 5% in patients 70 years of age. OH may complicate treatment of hypertension, heart failure, and coronary heart disease; cause disabling symptoms, faints, and traumatic injuries; and substantially reduce quality of life. Despite being largely asymptomatic or with minimal symptoms, the pres...
Source: Journal of the American College of Cardiology - August 10, 2015 Category: Cardiology Source Type: research
Relationship of Oxidized Phospholipids on Apolipoprotein B-100 to Cardiovascular Outcomes in Patients Treated With Intensive Versus Moderate Atorvastatin Therapy The TNT Trial
ConclusionsElevated OxPL-apoB levels predict secondary MACE in patients with stable CHD, a risk that is mitigated by atorvastatin 80 mg. (A Study to Determine the Degree of Additional Reduction in CV Risk in Lowering LDL Below Minimum Target Levels [TNT]; NCT00327691)
Source: Journal of the American College of Cardiology - March 30, 2015 Category: Cardiology Source Type: research
Alice in Lipidland The 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol ∗
In the topsy-turvy world of Lewis Carroll’s Alice in Wonderland(1), the Cheshire Cat said, “only a few find the way, some don’t recognize it when they do—some … don’t ever want to.” Such was the status of many healthcare providers and patients in November 2013 at the issuance of the 2013 American College of Cardiology/American Heart Association Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults (2). This was coupled with the Guideline on the Assessment of Cardiovascular Risk (3), using a new risk assessment calculator, the Pooled Cohort Equations (4), to es...
Source: Journal of the American College of Cardiology - November 24, 2014 Category: Cardiology Source Type: research
Reply: Effects of Habitual Coffee Consumption on Vascular Function
We thank Dr. Siasos and colleagues for pointing out that habitual coffee consumption has been associated with improved endothelial function in elderly inhabitants of Ikaria Island . The improvement in endothelial function may in part account for the associations of moderate coffee intake (about 2 to 4 cups daily) with lower risks for coronary heart disease and stroke . Indeed, even in the setting of endothelium damage, coffee has the ability to prevent arterial thrombus formation, a benefit that is independent of its caffeine content . Recent studies also indicate that moderate daily coffee intake may confer protection a...
Source: Journal of the American College of Cardiology - November 1, 2013 Category: Cardiology Authors: James J. DiNicolantonio, James H. O'Keefe, Carl J. Lavie Tags: Letters to the Editor Source Type: research
“De-Risking” Risk Reduction: Should Coronary Artery Calcium Scoring Be the Gatekeeper to Preventive Pharmacotherapy With the Polypill?∗
The cardiovascular disease (CVD) epidemic remains the leading cause of death worldwide . Widespread adoption of the Western diet and lifestyle by populations in emergent countries with low or middle income has resulted in dramatic increases in the incidence of coronary heart disease and stroke. An overwhelming proportion of the cardiovascular risk is explained by the cumulative presence of classic and potentially modifiable risk factors, and this effect does not seem to be influenced by sex, ethnicity, or geography . Therefore, to effectively reduce risk and improve outcomes, prevention strategies should be conducted and i...
Source: Journal of the American College of Cardiology - October 25, 2013 Category: Cardiology Authors: William Wijns, Dan Rusinaru Tags: Cardiometabolic Risk: Editorial Comment Source Type: research
The Year in Atherothrombosis
A number of studies have addressed the prevalence and significance of cardiovascular disease (CVD) worldwide. According to the Global Burden of Disease Study 2010, age-standardized death rates for CVD decreased by approximately 20% in the last 2 decades, but coronary heart disease (CHD) and stroke constitute the 2 leading causes of death in the world due to respective 35% and 26% increases in crude mortality () . Furthermore, when combining years of life lost and years lived with disability, CHD and stroke rank first and third, respectively . Amongst risk factors, arterial hypertension was identified as the main source of ...
Source: Journal of the American College of Cardiology - August 2, 2013 Category: Cardiology Authors: Javier Sanz, Pedro R. Moreno, Valentin Fuster Tags: YEAR IN CARDIOLOGY SERIES Source Type: research
Effects of Habitual Coffee Consumption on Cardiometabolic Disease, Cardiovascular Health, and All-Cause Mortality
Coffee, after water, is the most widely consumed beverage in the United States, and is the principal source of caffeine intake among adults. The biological effects of coffee may be substantial and are not limited to the actions of caffeine. Coffee is a complex beverage containing hundreds of biologically active compounds, and the health effects of chronic coffee intake are wide ranging. From a cardiovascular (CV) standpoint, coffee consumption may reduce the risk of type 2 diabetes mellitus and hypertension, as well as other conditions associated with CV risk such as obesity and depression; but it may adversely affect lipi...
Source: Journal of the American College of Cardiology - July 19, 2013 Category: Cardiology Authors: James H. O'Keefe, Salman K. Bhatti, Harshal R. Patil, James J. DiNicolantonio, Sean C. Lucan, Carl J. Lavie Tags: STATE-OF-THE-ART PAPER Source Type: research
