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Source: Neurology
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Total 259 results found since Jan 2013.

Cholesterol, Statins and the Risk of Dementia in the Oldest-Old: The 90+ Study (S58.003)
CONCLUSIONS: Contrary to studies reporting that high cholesterol is associated with decreased dementia in the oldest-old, we report that hypercholesterolemia was not associated with dementia while statin users were at decreased dementia risk. There are a variety of mechanisms by which statins may be neuroprotective including effects on amyloid production, neurofibrillary tangles, secondary stroke prevention, and other anti-inflammatory pleiotropic effects. Additional research is needed to explore other potential explanations for our results along with assessment of the effect of serum cholesterol levels and statin lipophil...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Evans, M., Kawas, C., Corrada, M. Tags: Aging, Dementia, and Cognitive and Behavioral Neurology: Clinical Aspects Source Type: research

Factor Scores for Brain Reserve, Alzheimer and Vascular Pathology are Independent Risk Factors for Dementia in a Population-based Cohort Study: The Kame Project (S58.006)
CONCLUSIONS: Brain reserve appears to play a very important role in buffering the effects of Alzheimer and vascular pathology on dementia risk. Simple reaction time, which clustered with education and verbal IQ, provides an easily-obtained measure of reserve.Study Supported by: NIA: R01 AG09769.Disclosure: Dr. Borenstein has nothing to disclose. Dr. Mortimer has nothing to disclose. Dr. Larson has received royalty payments from UpToDate.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Borenstein, A., Mortimer, J., Larson, E. Tags: Aging, Dementia, and Cognitive and Behavioral Neurology: Clinical Aspects Source Type: research

Post-Surgical Cognitive Outcomes (S62.001)
CONCLUSIONS:Patients who undergo AVR demonstrate persistent cognitive decline characterized by diminished learning on tests of memory and language and related to perioperative clinical stroke. These findings underscore the importance of ischemic neurologic complications of surgery and the need for improved stroke prevention and treatment strategies.Study Supported by: R01HL084375 to T.F.F.Disclosure: Dr. Giovannetti has nothing to disclose. Dr. Fanning has nothing to disclose. Dr. Ratcliffe has nothing to disclose. Dr. Price has nothing to disclose. Dr. Messe has received personal compensation for activities with GlaxoSmit...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Giovannetti, T., Fanning, M., Ratcliffe, S., Price, C., Messe, S., Selnes, O., Acker, M., Floyd, T., Szeto, W., Bavaria, J. Tags: Cerebrovascular Disease and Interventional Neurology: Cognitive and Behavioral Source Type: research

Comparing Semi-quantitative and Volumetric Measurements of MRI White Matter Hyperintensities: The Northern Manhattan Study (S62.007)
CONCLUSIONS: Our volumetric and visual rating measures of WMH were strongly correlated, but the volumetric measure was associated with more risk factors in this community-based sample. User-friendly WMH scales that capture vascular risk are needed to develop risk-prediction scores for WMH lesion burden.Study Supported by:Evelyn F. McKnight Brain Institute and NINDS (R37 NS 29993; K02 NS 059729)Disclosure: Dr. Oboudiyat has nothing to disclose. Dr. Gardener has nothing to disclose. Dr. Marquez has nothing to disclose. Dr. Sacco has nothing to disclose. Dr. DeCarli has received personal compensation in an editorial capacity ...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Oboudiyat, C., Gardener, H., Marquez, C., Elkind, M., Sacco, R., DeCarli, C., Wright, C. Tags: Cerebrovascular Disease and Interventional Neurology: Cognitive and Behavioral Source Type: research

Stroke Mortality And Its Predictors In Nigeria: Results Of A Hospital-Based Study (I10-1.008)
Conclusion: The 30-day case fatality rate among our stroke patients is high while the independent predictors of this outcome are severity of stroke on admission and presence of complications. Continuing health education of the public on stroke recognition and the need for early hospital presentation is necessary while optimal management of cases in a stroke care unit is advocated in order to improve outcome.Disclosure: Dr. Wahab has nothing to disclose. Dr. Sanya has nothing to disclose. Dr. Ademiluyi has nothing to disclose. Dr. Abiodun has nothing to disclose. Dr. Alaofin has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Wahab, K., Sanya, E., Ademiluyi, B., Abiodun, B., Alaofin, W. Tags: The Global Burden of Neurological Diseases Poster Presentations Source Type: research

The Association between Meeting Life's Simple 7 Goals and Mortality after Stroke in the US (I10-2.001)
CONCLUSIONS: Meeting a greater number of cardiovascular health metrics was associated with lower all-cause mortality after stroke in an inverse dose-dependent fashion, suggesting that interventions specifically targeting these 7 factors could have a profound impact on long-term outcomes after stroke.Disclosure: Dr. Lin has nothing to disclose. Dr. Markovic has nothing to disclose. Dr. Ovbiagele has nothing to disclose. Dr. Towfighi has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Lin, M., Markovic, D., Ovbiagele, B., Towfighi, A. Tags: The Global Burden of Neurological Diseases Data Blitz Presentations Source Type: research

Indonesia Stroke Registry (I10-2.003)
Conclusion: Having the high prevalence of first ever and recurrent stroke, hypertension is the most common risk factor for both ischemic and hemorrhage stroke. This study was very useful for our country and our specialty to make some national plans to educate people to modify the life style, to train the general practitioners in primary health care as the first gate health service to provide community program for controlling some risk factors of stroke, Those must be the first priority of combating stroke in IndonesiaKeywords: Stroke registry, risk factor, functional outcome, cognitive outcomeDisclosure: Center for Applied...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Yudiarto, F., Machfoed, M., Darwin, A., Ong, A., Karyana, M., Siswanto, Tags: The Global Burden of Neurological Diseases Data Blitz Presentations Source Type: research

Helping Haiti: Addressing the Burden of Neurologic Disease (I10-2.004)
CONCLUSIONS: With this nationwide collaborative and interdisciplinary approach, we hope to have a dramatic impact on the perceptions and outcomes of neurologic disease and provide a continuous, but dynamic presence in Port au Prince, Haiti while training physicians, nurses, and other team members in global health perspectives.Disclosure: Dr. Santini has nothing to disclose. Dr. Alessi has received personal compensation for activities with CBS Radio, the National Football League Players Association, and Colonial Cooperative Care. Dr. Jones has nothing to disclose. Dr. Etienne has nothing to disclose. Dr. Hohler has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Santini, V., Alessi, A., Jones, E., Etienne, M., Hohler, A. Tags: The Global Burden of Neurological Diseases Data Blitz Presentations Source Type: research

Long Distance Travel Potentiates Other Novel Risk Factors in PFO Related Strokes - "Economy Class Strokes" (S55.006)
ConclusionPFOs are highly prevalent in the general population, but they are usually only discovered after a stroke - so effective risk assessment and prevention are key. Our results suggest that both air and land travel are risk factors for PFO-related stroke, and the coexistence of additional risk factors potentiates risk associated with immobilization. These results help to individualize care: high-risk patients may benefit from pre-travel education, or DVT prophylaxis.Study Supported by: NIH/NINDSDisclosure: Dr. Ning has nothing to disclose. Dr. Sena has nothing to disclose. Dr. Feeney has nothing to disclose. Dr. Wickh...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Ning, M., Sena, D., Feeney, K., Wickham, T., Elia, M., Deng, W., Chou, I., Hung, J., Chen, L., Inglessis-Azuaje, I., Silverman, S., Schainfeld, R., McMullin, D., Dec, G., Lo, E., Palacios, I., Buonanno, F. Tags: Pediatric Stroke and Stroke in the Young Source Type: research

Intracranial artery stenosis and progression from mild cognitive impairment to Alzheimer disease
Conclusions: Intracranial arterial stenosis increased the risk of developing AD dementia after MCI.
Source: Neurology - March 10, 2014 Category: Neurology Authors: Zhu, J., Wang, Y., Li, J., Deng, J., Zhou, H. Tags: All Cerebrovascular disease/Stroke, All Cognitive Disorders/Dementia, Alzheimer's disease, MCI (mild cognitive impairment) ARTICLE Source Type: research

Randomized Evaluation of Carotid Occlusion and Neurocognition (RECON) trial: Main results
Conclusion: Cognitive improvement following bypass surgery was not superior to medical therapy among patients with recently symptomatic carotid occlusion and increased OEF. Among those with no recurrent stroke, less hemodynamic impairment at baseline was associated with greater cognitive gain in both groups. Reversing cognitive impairment in hemodynamic failure remains an open challenge. Classification of evidence: This study provides Class II evidence that for patients with symptomatic ICA occlusion and increased OEF on PET, EC-IC bypass compared to no bypass does not improve cognitive function after 2 years.
Source: Neurology - March 3, 2014 Category: Neurology Authors: Marshall, R. S., Festa, J. R., Cheung, Y.-K., Pavol, M. A., Derdeyn, C. P., Clarke, W. R., Videen, T. O., Grubb, R. L., Slane, K., Powers, W. J., Lazar, R. M., On behalf of the RECON Investigators Tags: PET, All Cerebrovascular disease/Stroke, Clinical trials Randomized controlled (CONSORT agreement), Vascular dementia ARTICLE Source Type: research

Emerging Subspecialties in Neurology: Palliative care
As we work to find cures for so many devastating neurologic injuries and diseases, our patients suffer tremendously on a daily basis. Individuals with conditions including stroke, multiple sclerosis, Parkinson disease (PD), muscular dystrophies, amyotrophic lateral sclerosis (ALS), and nervous system malignancies share a host of physical, emotional, and existential symptoms that can be difficult to treat. In addition, patients and their families face the realities of loss of function, loss of ability to communicate, and lifespans limited by the neurologic diagnosis or complications related to it (e.g., dysphagia, immobilit...
Source: Neurology - February 17, 2014 Category: Neurology Authors: Dallara, A., Tolchin, D. W. Tags: All Clinical Neurology, All Education, Palliative care RESIDENT AND FELLOW SECTION Source Type: research

Thrombolytic utilization for ischemic stroke in US hospitals with neurology residency program
Conclusions: Acute stroke care in NR hospitals is associated with an increased thrombolytic utilization. The disparities between the thrombolysis rate in NR and that in OT and NT hospitals are greater among elderly patients.
Source: Neurology - December 2, 2013 Category: Neurology Authors: Moradiya, Y., Crystal, H., Valsamis, H., Levine, S. R. Tags: Medical care, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

How experienced community neurologists make diagnoses during clinical encounters
We describe 3 core domains of diagnosis: 1) clinical (C), 2) laboratory and electrodiagnostics (L), and 3) neuroimaging (N). Neurologists were uniform in their practices across these domains except within the clinical domain, where the physical examination varied considerably among clinicians. All neurologists coordinated findings from the 3 domains to arrive at a final diagnosis. This practice of coordination varied across common disease categories (e.g., meningitis vs dementia). To codify this variance, we developed a provisional model of diagnostic practice derived from the data consisting of a 3-point coordinate shorth...
Source: Neurology - October 14, 2013 Category: Neurology Authors: Dhand, A., Engstrom, J., Dhaliwal, G. Tags: Cost effectiveness/economic, Decision analysis, All Clinical Neurology, Methods of education CONTEMPORARY ISSUES Source Type: research

Risk factors for dementia with Lewy bodies: A case-control study
Conclusion: DLB risk factors are an amalgam of those for AD and PD. Smoking and education, which have opposing risk effects on AD and PD, are not risk factors for DLB; however, depression and low caffeine intake, both risk factors for AD and PD, increase risk of DLB more strongly than in either.
Source: Neurology - August 26, 2013 Category: Neurology Authors: Boot, B. P., Orr, C. F., Ahlskog, J. E., Ferman, T. J., Roberts, R., Pankratz, V. S., Dickson, D. W., Parisi, J., Aakre, J. A., Geda, Y. E., Knopman, D. S., Petersen, R. C., Boeve, B. F. Tags: Parkinson's disease/Parkinsonism, All Cognitive Disorders/Dementia, Alzheimer's disease, Dementia with Lewy bodies, Case control studies ARTICLE Source Type: research