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Protein-Drug Interactome Analysis of SSRI-mediated Neurorecovery following Stroke.
Abstract Serotonin selective reuptake inhibitors (SSRIs) have been widely used as first-line drugs in the treatment of a range of depressive and anxiety disorders. Recently, clinical studies found that this class of agents also shows significant efficacy in promoting neurogenesis, neuroplasticity and neurorecovery following stroke. Here, we attempt to elucidate molecular mechanism and biological implication underlying the SSRI-mediated neurorecovery. In the procedure, a comprehensive protein-drug interactome (PDI) was constructed for various SSRIs and their major metabolites as well as a group of control drugs acr...
Source: Biosystems - April 3, 2014 Category: Biotechnology Authors: Chen HF, Pan XL, Wang JW, Kong HM, Fu YM Tags: Biosystems Source Type: research