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Fixed ‐dose vs free‐dose combinations for the management of hypertension—An analysis of 81 958 patients
Fixed‐dose combinations (FDC) have been developed to reduce the pill burden for hypertensive patients. Data on fixed‐dose or free‐dose (freeDC) ramipril/amlodipine (R/A) or candesartan/amlodipine (C/A) combination treatment initiation were assessed. 71 463 patients were prescribed R/A and 10 495 C/A. For both R/A and C/A, FDC patients were younger (both P < .001) and less comorbid. Prior MI (OR: 0.61 and 0.60), prior stroke (OR: 0.68 and 0.70) and CHD (OR: 0.68 and 0.64) were negatively associated with FDC use, whereas hyperlipidemia was positively associated (OR: 1.26 and 1.19). Use of antihypertensive comedi...
Source: The Journal of Clinical Hypertension - February 19, 2018 Category: Cardiology Authors: Peter Bramlage, Stefanie Schmidt, Helen Sims Tags: ORIGINAL PAPER Source Type: research

Amlodipine+Benazepril is Superior to Hydrochlorothiazide+Benazepril Irrespective of Baseline Pulse Pressure: Subanalysis of the ACCOMPLISH Trial
Pulse pressure (PP) is an independent risk factor for cardiovascular (CV) disease and death but few studies have investigated the effect of antihypertensive treatments in relation to PP levels before treatment. The Avoiding Cardiovascular Events Through Combination Therapy in Patients Living With Systolic Hypertension (ACCOMPLISH) trial showed that the combination of benazepril+amlodipine (B+A) is superior to benazepril+hydrochlorothiazide (B+H) in reducing CV events. We aimed to investigate whether the treatment effects in the ACCOMPLISH trial were dependent on baseline PP. High‐risk hypertensive patients (n=11,499) wer...
Source: The Journal of Clinical Hypertension - December 22, 2014 Category: Cardiology Authors: Per H. Skoglund, Per Svensson, Joline Asp, Björn Dahlöf, Sverre E. Kjeldsen, Kenneth A. Jamerson, Michael A. Weber, Yan Jia, Dion H. Zappe, Jan Östergren, Tags: Original Paper Source Type: research