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Therapy: Stem Cell Therapy
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Total 1 results found since Jan 2013.
Smurf2‐mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke
Abstract
EZH2 plays an important role in stem cell renewal and maintenance by inducing gene silencing via its histone methyltransferase activity. Previously, we showed that EZH2 downregulation enhances neuron differentiation of human mesenchymal stem cells (hMSCs); however, the underlying mechanisms of EZH2‐regulated neuron differentiation are still unclear. Here, we identify Smurf2 as the E3 ubiquitin ligase responsible for the polyubiquitination and proteasome‐mediated degradation of EZH2, which is required for neuron differentiation. A ChIP‐on‐chip screen combined with gene microarray analysis revealed that PPAR...
Source: EMBO Molecular Medicine - March 25, 2013 Category: Molecular Biology Authors: Yung‐Luen Yu, Ruey‐Hwang Chou, Woei‐Cherng Shyu, Shu‐Ching Hsieh, Chen‐Shiou Wu, Shu‐Ya Chiang, Wei‐Jung Chang, Jia‐Ni Chen, Yen‐Ju Tseng, Yu‐Hsuan Lin, Wei Lee, Su‐Peng Yeh, Jennifer L. Hsu, Cheng‐Chieh Yang, Shih‐Chieh Hung, Mi Tags: Research Article Source Type: research
