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The Triangulation WIthin a STudy (TWIST) framework for causal inference within pharmacogenetic research
by Jack Bowden, Luke Pilling, Deniz T ürkmen, Chia-Ling Kuo, David Melzer
In this paper we review the methodological underpinnings of the general pharmacogenetic approach for uncovering genetically-driven treatment effect heterogeneity. This typically utilises only individuals who are treated and relies on fairly strong baseline assumptions to estimate what we term the ‘genetically moderated treatment effect’ (GMTE). When these assumptions are seriously violated, we show that a robust but less efficient estimate of the GMTE that incorporates information on the population of untreated individuals can instead be used. ...
Source: PLoS Genetics - September 8, 2021 Category: Genetics & Stem Cells Authors: Jack Bowden Source Type: research
