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N-3 polyunsaturated fatty acids in animal models with neuroinflammation: An update.
Abstract Neuroinflammation is a characteristic of a multitude of neurological and psychiatric disorders. Modulating inflammatory pathways offers a potential therapeutic target in these disorders. Omega-3 polyunsaturated fatty acids have anti-inflammatory and pro-resolving properties in the periphery, however, their effect on neuroinflammation is less studied. This review summarizes 61 animal studies that tested the effect of omega-3 polyunsaturated fatty acids on neuroinflammatory outcomes in vivo in various models including stroke, spinal cord injury, aging, Alzheimer's disease, Parkinson's disease, lipopolysacch...
Source: European Journal of Pharmacology - May 30, 2015 Category: Drugs & Pharmacology Authors: Trépanier MO, Hopperton KE, Orr SK, Bazinet RP Tags: Eur J Pharmacol Source Type: research