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The holy grail of epilepsy prevention: preclinical approaches to antiepileptogenic treatments.
Abstract A variety of acute brain insults can induce epileptogenesis, a complex process that results in acquired epilepsy. Despite advances in understanding mechanisms of epileptogenesis, there is currently no approved treatment that prevents the development or progression of epilepsy in patients at risk. The current concept of epileptogenesis assumes a window of opportunity following acute brain insults that allows intervention with preventive treatment. Recent results suggest that injury-induced epileptogenesis can be a much more rapid process than previously thought, suggesting that the 'therapeutic window' may...
Source: Neuropharmacology - April 9, 2019 Category: Drugs & Pharmacology Authors: Löscher W Tags: Neuropharmacology Source Type: research