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Waking up to new treatments for stroke - WAKE-UP trial starts in the UK
WAKE-UP - a large European clinical trial to test whether current 'clot dissolving' treatments can be used in people who wake up with the symptoms of stroke enrolled the first UK patients at the Southern General Hospital this week. Every year about two million patients have a stroke in the EU. Up to 20 per cent of stroke patients wake up with stroke symptoms so the time the stroke started is unknown. This makes patients ineligible for the only approved treatment for acute stroke- the delivery the thrombolytic or 'clot dissolving' drug rtPA...
Source: Health News from Medical News Today - July 29, 2013 Category: Consumer Health News Tags: Stroke Source Type: news

Speed Vital For Stroke Patients' Survival
The sooner stroke patients receive thrombolytic treatment, the lower their risk of in-hospital mortality and intracranial hemorrhage, says a new study published in JAMA (Journal of the American Medical Association). In addition, the prompter the treatment, the higher the rate of walking ability at discharge. Intravenous (IV) tissue-type plasminogen activator (tPA) is a form of treatment proven to help stroke patients within 4.5 hours of onset of symptoms...
Source: Health News from Medical News Today - June 19, 2013 Category: Consumer Health News Tags: Stroke Source Type: news

Earlier Treatment Following Stroke Onset Associated With Reduced Risk Of In-Hospital Death, Higher Rate Of Discharge To Home
In a study that included nearly 60,000 patients with acute ischemic stroke, thrombolytic treatment (to help dissolve a blood clot) that was started more rapidly after symptom onset was associated with reduced in-hospital mortality and intracranial hemorrhage and higher rates of independent walking ability at discharge and discharge to home, according to a study in the June 19 issue of JAMA. "Intravenous (IV) tissue-type plasminogen activator (tPA) is a treatment of proven benefit for select patients with acute ischemic stroke as long as 4.5 hours after onset...
Source: Health News from Medical News Today - June 20, 2013 Category: Consumer Health News Tags: Stroke Source Type: news

Stroke risk 'higher at start of warfarin treatment'
Conclusion This study has found that warfarin was associated with an increased risk of ischaemic stroke during the first 30 days of treatment. After 30 days of treatment, warfarin was associated with a decreased risk of stroke. However, this study has a number of limitations that should be considered: All information was from patient records, which means that it wasn't subject to recall bias, but the information may not be complete – we do not know if, for example, people took the medication they were prescribed. There may be other factors (confounders) that explain the association seen. In particular, the ba...
Source: NHS News Feed - December 19, 2013 Category: Consumer Health News Tags: Heart/lungs Medication Source Type: news

HRT review finds increased risk of blood clots and stroke
Conclusion This updated Cochrane review has found that oral HRT increases risk of stroke and blood clots, and does not appear to reduce overall risk of cardiovascular disease or death during follow-up. More exploratory analyses suggested that HRT might reduce risk of death from heart disease or non-fatal heart attack if it was started within 10 years of menopause, but this finding needs further confirmation. The review was carried out using robust methods and the trials were of good quality. Its findings are in line with the previous version of the review, and also with other reviews. There are some points to note: Thi...
Source: NHS News Feed - March 10, 2015 Category: Consumer Health News Tags: Heart/lungs Medication Source Type: news

Reversing the effects of the new anti-clotting drugs
The oral anticoagulant warfarin (Coumadin) became available for prescription in 1954. This anti-clotting drug commanded national attention when President Dwight Eisenhower received the drug as part of his treatment following a heart attack. No other oral anticoagulant was successfully developed and marketed in the United States until 2010. Warfarin is a dangerous drug. Along with insulin, it is responsible for the most emergency hospitalizations due to adverse drug reactions. Whereas insulin causes low blood sugar, warfarin is notorious for the complication of major bleeding. Warfarin is plagued by hundreds of drug-drug an...
Source: New Harvard Health Information - December 9, 2015 Category: Consumer Health News Authors: Samuel Z. Goldhaber, MD Tags: Drugs and Supplements Health Heart Health Hypertension and Stroke anti-clotting coumadin deep-vein-thrombosis DVT Source Type: news

Thrombolysis After 'Wake-Up Stroke' FeasibleThrombolysis After 'Wake-Up Stroke' Feasible
Preliminary findings add to increasing data suggesting that thrombolytic treatment in patients who wake up with stroke symptoms is feasible, beneficial. Medscape Medical News
Source: Medscape Medical News Headlines - October 27, 2014 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Risk Communication in Hyperacute Stroke ThrombolysisRisk Communication in Hyperacute Stroke Thrombolysis
A new study identifies variations among clinicians in the risk communication of thrombolytic therapy for hyperacute stroke. What strategies could better help patients understand the risks? Emergency Medicine Journal
Source: Medscape Today Headlines - May 21, 2015 Category: Consumer Health News Tags: Emergency Medicine Journal Article Source Type: news

Ischemic Stroke Complicating Thrombolytic Therapy for STEMI Ischemic Stroke Complicating Thrombolytic Therapy for STEMI
These two cases highlight the rare complication of ischemic stroke following fibrinolytic therapy for STEMI. What mechanism might explain this paradoxical occurrence?Journal of Medical Case Reports
Source: Medscape Today Headlines - August 21, 2017 Category: Consumer Health News Tags: Internal Medicine Journal Article Source Type: news

The Case Against Thrombolytic Therapy in Stroke The Case Against Thrombolytic Therapy in Stroke
A New York Times article siding with neurologists in their debate with emergency medicine over the benefits of tPA in ischemic stroke prompted Dr Mandrola to take a closer look at the data.theheart.org on Medscape
Source: Medscape Today Headlines - April 13, 2018 Category: Consumer Health News Tags: Cardiology Expert Column Source Type: news

tPA in Stroke: ' The Facts Are Clear ' tPA in Stroke: ' The Facts Are Clear '
Thrombolytic treatment for stroke remains controversial among specialties. Here, a neurologist argues for its use.Medscape Neurology
Source: Medscape Today Headlines - April 20, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery Expert Column Source Type: news

Thrombus Imaging in Acute Stroke: Are We Even Close? Thrombus Imaging in Acute Stroke: Are We Even Close?
Can imaging characteristics of thrombi provide predictive value or useful information for planning endovascular procedures?Stroke
Source: Medscape Today Headlines - October 4, 2019 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

rt-PA in Ischemic Stroke After Idarucizumab Administration rt-PA in Ischemic Stroke After Idarucizumab Administration
This case demonstrates that thrombolytic therapy with rt-PA after reversal of dabigatran with idarucizumab may be safe and feasible in patients with acute ischemic stroke with lacunar infarct.Journal of Medical Case Reports
Source: Medscape Today Headlines - February 4, 2020 Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news

MRI Tool Helps Spot Damage to Blood-Brain Barrier in StrokeMRI Tool Helps Spot Damage to Blood-Brain Barrier in Stroke
A software tool used with standard MRI may provide a clearer picture of the extent of damage to the blood-brain barrier in acute stroke, possibly helping to predict risk for ICH with thrombolytic therapy. Medscape Medical News
Source: Medscape Today Headlines - January 23, 2013 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

CLOTS 3: Inflatable Leg Sleeves Reduce DVT in StrokeCLOTS 3: Inflatable Leg Sleeves Reduce DVT in Stroke
Intermittent pneumatic compression of the legs with inflatable sleeves reduced the occurrence of deep vein thrombosis (DVT) in immobile patients who had had a recent stroke. Medscape Medical News
Source: Medscape Today Headlines - June 2, 2013 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

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