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Sneddon's syndrome: it is all in the ectoderm.
Abstract A 51-year-old man gave a 2-year history of worsening mobility, cognitive decline and headaches. He had a history of thromboembolic stroke, recurrent transient ischaemic attacks and a spontaneous intraventricular haemorrhage. On examination, he had livedo reticularis and perniosis and a systolic murmur. Catheter cerebral angiography showed peripheral small-vessel and medium-vessel vasculopathy resulting in pruning of the distal cortical vessels and tortuous irregular distal collaterals. Skin biopsy showed subtle vasculopathy with ectasia of capillaries and postcapillary venules but no frank vasculitis or a...
Source: Practical Neurology - March 11, 2016 Category: Neurology Authors: Rutter-Locher Z, Chen Z, Flores L, Basu T, Creamer D, Weeks R, Arya R, Nashef L Tags: Pract Neurol Source Type: research