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CHA2DS2VASc Score as a Predictor for Thromboembolic Stroke in Patients with Cardiac Aneurysm
Background: Patients with atrial fibrillation (AF) are at an increased risk of stroke due to increased propensity for thrombus formation in the left atrium secondary to sluggish blood flow. CHA2DS2VASc score is used to predict the risk of stroke in these patients, and treat them accordingly. Similarly, there is poor flow in cardiac aneurysms (CA) which increase thrombus formation and risk for thromboembolic stroke. Data on CHA2DS2VASc score as a predictor of thromboembolic stroke in CA is limited.
Source: Journal of Cardiac Failure - August 1, 2017 Category: Cardiology Authors: Siva Sagar Taduru, Shubha Deep Roy, Madhuri Ramakrishnan, Dushyant Ramakrishnan, Alankrita Taneja, Paramdeep Baweja Source Type: research

Increased Risk of Thromboembolic Events Following Gastrointestinal Bleeds among Left Ventricular Assist Device Patients
Introduction: Patients with left ventricular assist devices (LVADs) are typically treated with warfarin and aspirin to prevent pump thrombosis and ischemic stroke. It has been observed that LVAD patients have a high incidence of bleeding complications, most commonly from the gastrointestinal tract. Patients who experience gastrointestinal bleeds (GIB) requiring hospitalization typically undergo a reduction in their anticoagulation and/or antiplatelet regimen. Few studies have examined the relationship between GIB and thromboembolic (TE) events in this population.
Source: Journal of Cardiac Failure - August 1, 2017 Category: Cardiology Authors: Eric W. Rudofker, Saadia Sherazi, John D. Rice, Brent A. Johnson, Jeffrey D. Alexis Source Type: research

Apixaban Use in LVAD Patient with Recurrent GI Bleeding and Recent Embolic Stroke
Background: Left ventricular assist devices (LVAD) have been shown to improve quality of life and decrease mortality in patients with advanced heart failure. GI bleeding and pump thrombosis are major complications associated with LVAD therapy. Warfarin is the mainstay of anticoagulation for these patients. However, warfarin therapy can be challenging due to a narrow therapeutic window, drug/food interactions and need for frequent monitoring. The direct oral anticoagulants (DOACs) have been shown to be non-inferior or superior to warfarin for preventing stroke and reducing the risk of bleeding in patients with AF.
Source: Journal of Cardiac Failure - July 23, 2016 Category: Cardiology Authors: Lisa Curran, Ali Cosgrove, Amy Clegg, Molly Reece, Bryan Bartle, Peter Van Trigt, Dalton McLean, Daniel Bensimhon Source Type: research

Increased Risk of LVAD Thrombosis in Patients With a Previous History Thromboembolic Event
Heart failure is a clinical syndrome that affects more than 5.1 million Americans and over 23 million individuals worldwide. With the likely substantial growth in the incidence and prevalence of heart failure patients over the next 20-40 years, there will also likely be a corresponding increasein the need for left ventricular assist devices (LVADs). Complications occur and consist primarily of infection, stroke or other thromboembolic event, device malfunction, bleeding, and pump thrombosis. Since LVAD thrombosis can have devastating consequences, including central or peripheral thromboembolism, LVAD malfunction or failure...
Source: Journal of Cardiac Failure - July 31, 2015 Category: Cardiology Authors: Scott Lundgren Tags: Clinical Care I Source Type: research

Thrombolytic Therapy for Thrombosis of Continuous Flow Ventricular Assist Devices
Conclusions: In the setting of LVAD thrombosis, thrombolytic therapy is an alternate treatment strategy in a subset of patients. Candidacy for this alternate procedure must carefully weigh the risks of complications, including hemorrhage and thromboembolism.
Source: Journal of Cardiac Failure - December 19, 2013 Category: Cardiology Authors: Kelly Schlendorf, Chetan B. Patel, Thomas Gehrig, Todd L. Kiefer, G. Michael Felker, Adrian F. Hernandez, Laura J. Blue, Carmelo A. Milano, Joseph G. Rogers Tags: Clinical Investigations Source Type: research

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