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Presence of intracardiac thrombus at the time of left ventricular assist device implantation is associated with increased risk of stroke and death
Left ventricular assist device
Source: Journal of Cardiac Failure - June 20, 2021 Category: Cardiology Authors: Claudio A. Bravo, Justin A. Fried, Joshua Z. Willey, Azka Javaid, Giulio M. Mondellini, Lorenzo Braghieri, Heidi Lumish, Veli K. Topkara, Yuji Kaku, Lucas Witer, Hiroo Takayama, Koji Takeda, Gabriel Sayer, Nir Uriel, Ryan T. Demmer, Yoshifumi Naka, Melana Source Type: research

Hemodynamic Aberrancies in Left Ventricular Assist Device Associated Heart Failure Syndromes
The advent of the fully magnetically levitated HeartMate 3 LVAD has enabled a marked reduction in hemocompatibility-related adverse events, with a near-elimination of pump thrombosis, and a marked decrease in stroke in LVAD recipients.1,2 As a result, a survival benchmark for LVAD therapy has been established – prolongation of median survival more than 5-years, in patients with advanced heart failure with otherwise severely limited 1-year survival.3
Source: Journal of Cardiac Failure - September 25, 2022 Category: Cardiology Authors: Jacinthe Boulet, Aditi Nayak, Mandeep R. Mehra Tags: JCF Ignite! Source Type: research

Hemodynamic Aberrancies in Left Ventricular Assist Device –Associated Heart Failure Syndromes
The advent of the fully magnetically levitated HeartMate 3 left ventricular assist device (LVAD) has enabled a marked reduction in hemocompatibility-related adverse events, with a near-elimination of pump thrombosis, and a marked decrease in stroke in LVAD recipients.1,2 As a result, a survival benchmark for LVAD therapy has been established —prolongation of the median survival of more than 5 years in patients with advanced heart failure with otherwise severely limited 1-year survival.3
Source: Journal of Cardiac Failure - September 25, 2022 Category: Cardiology Authors: JACINTHE Boulet, ADITI Nayak, MANDEEP R. Mehra Tags: JCF Ignite! Source Type: research

Risk Of Pump Thrombosis With Once Daily Enoxaparin For Anticoagulation Bridging In Patients With Heartmate III
Most centers bridge patients with Left Ventricular Assist Device (LVAD) with heparin drip to avoid thromboembolic complications including stroke and pump thrombosis based on data from HeartMate II. Because of improved hemocompatibility of third generation HeartMateIII (HM3), particularly the decreased risk of in-pump thrombosis, outpatient treatment dose of low molecule weight heparin (LWMH) like Enoxaparin has been used to bridge to warfarin when the INR is subtherapeutic. Once daily dosing has been used in select patients with higher bleeding risk.
Source: Journal of Cardiac Failure - April 1, 2023 Category: Cardiology Authors: Modar Alom, Gurjaspreet Bhattal, Nitin Kabra, David Rawitscher, Amit Alam, Cesar Guerrero-Miranda, Sandra Carey, Timothy George, Aasim Afzal Tags: 180 Source Type: research

Von Willebrand Factor Activation Assays Predict Bleeding And Other Hemocompatibility-Related Adverse Events In Patients With CF-LVAD.
Bleeding and hemocompatibility-related adverse events (HRAEs - bleeding, neurological event, stroke, arterial thrombosis, pump thrombosis, and death) remain significant in LVAD patients; changes in coagulation homeostasis, mainly due to von Willebrand Factor (vWF) structural and functional changes induced by mechanical support have been considered a major player in these adverse events. However, the specific mechanisms and the clinical correlation between coagulation profile parameters and clinical outcomes are not yet completely clarified.
Source: Journal of Cardiac Failure - April 1, 2023 Category: Cardiology Authors: Bansi Vekaria, Eleonora Avenatti, Aayush Shah, Ju Kim, Rayan Yousefzai, Imad Hussain, Ashrith Guha, Arvind Bhimaraj, Janardhana Gorthi, Jian Chen, Edward A Graviss, Duc T Nguyen, Marcos De Oliveira, Lin-Chiang Philip Chou, Erik Suarez, Thomas E. MacGilliv Tags: 193 Source Type: research

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