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Left Atrial Appendage Thrombus in Transcatheter Aortic Valve Replacement: Incidence, Clinical Impact, and the Role of Cardiac Computed Tomography
Conclusions The incidence of LAAT in patients considered for TAVR is high, and LAAT embolization may represent a clinically relevant cause of periprocedural stroke. Dual-phase CCT is an accurate modality for the diagnosis of LAAT. It may obviate the need for pre-procedural TEE. The presence of LAAT should be examined in all patients undergoing TAVR and strategies developed for those patients in whom LAAT is identified.
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - January 15, 2017 Category: Cardiology Authors: Palmer, S., Child, N., de Belder, M. A., Muir, D. F., Williams, P. Tags: Structural Source Type: research

Interventional Cryoablation Therapy of Paroxysmal Atrial Fibrillation in Young Patients With Low CHADS 2 Score Worth the Risk of Periprocedural and Long-Term Adverse Events?
In this study the long-term effectiveness in the cryoablation group was reported as 69.9% after 12 months, with a mean fluoroscopy exposure time of 63 min. Regarding the adverse events during follow-up, only 1 adverse event (1.2%) occurred in the drug therapy arm (transfusion because of hemorrhage) compared with 32 adverse events (14.2%) in the cryoablation group, not regarding the 24 patients who suffered temporary phrenic nerve palsy. Five strokes, 4 transient ischemic attacks, 2 cases of tamponades, 2 myocardial infarctions, 3 transfusions, 2 atriovenous fistulas, 2 pseudoaneurysms, 4 cases of persistent phrenic nerve...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - September 23, 2013 Category: Cardiology Source Type: research

In Vivo Evaluation of Atherosclerotic Plaque Inflammation and of Anti-Inflammatory Effects of Statins by 18 F-Fluorodeoxyglucose Positron Emission Tomography ∗
Atherosclerosis is currently no longer considered merely a cholesterol storage disease, but rather a complex process of vascular inflammation (1,22). Indeed, various inflammatory cells and, in particular, monocytes and macrophages play a major role in the development, progression, and rupture of atherosclerotic plaques (3). Atherosclerosis is initiated when blood monocytes and T lymphocytes are attracted by chemokinesis to oxidized apo-B rich lipoproteins in the vessel wall. Expression of vascular cell adhesion molecule-1 and E- and P-selectin by the endothelium allows their adherence and entry into the subendothelial spac...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - August 26, 2013 Category: Cardiology Source Type: research