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Edoxaban: Review of Pharmacology and Key Phase I to III Clinical Trials
Vitamin K antagonists (VKAs) remain the standard therapy for anticoagulation in prevention and treatment of venous thromboembolism (VTE) and for the prevention of stroke in atrial fibrillation (AF). Due to numerous limitations of VKAs, target-specific oral anticoagulants have been developed. Edoxaban is a direct activated factor X inhibitor with attractive features among which are once daily dosing, no need for routine monitoring, and minimal drug–drug interactions. In patients undergoing orthopedic surgery, edoxaban was superior to enoxaparin in preventing VTE. Furthermore, a recent large-scale phase III trial in pa...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - August 13, 2014 Category: Cardiology Authors: Plitt, A., Giugliano, R. P. Tags: Reviews Source Type: research