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Source: AJP: Heart and Circulatory Physiology
Condition: Thrombosis
Drug: Solodyn
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Total 1 results found since Jan 2013.
Targets of vascular protection in acute ischemic stroke differ in type 2 diabetes
The objective of the present study was to determine the effects of acute manipulation of potential targets for vascular protection [i.e., NF-B, peroxynitrite, and matrix metalloproteinases (MMPs)] on vascular injury and functional outcome in a diabetic model of cerebral ischemia. Ischemia was induced by middle cerebral artery occlusion in control and type 2 diabetic Goto-Kakizaki rats. Treatment groups received a single dose of the peroxynitrite decomposition catalyst 5,10,15,20-tetrakis(4-sulfonatophenyl)prophyrinato iron (III), the nonspecific NF-B inhibitor curcumin, or the broad-spectrum MMP inhibitor minocycline at re...
Source: AJP: Heart and Circulatory Physiology - March 15, 2013 Category: Cardiology Authors: Kelly-Cobbs, A. I., Prakash, R., Li, W., Pillai, B., Hafez, S., Coucha, M., Johnson, M. H., Ogbi, S. N., Fagan, S. C., Ergul, A. Tags: VASCULAR BIOLOGY AND MICROCIRCULATION Source Type: research
