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Orthostatic hypotension and cardiovascular risk.
Abstract Orthostatic hypotension (OH) is a cardinal sign of cardiovascular (CV) autonomic dysfunction as a result of autonomic nervous system failure to control the postural hemodynamic homeostasis. The proportion of individuals with OH increases with aging and chronic conditions, such as neurodegenerative diseases, hypertension, heart failure, diabetes, renal dysfunction, autoimmune diseases and cancer. In those over 70 years, more than 20% can be affected. It is now increasingly recognized that a direct relationship exists between OH and each step of the CV disease continuum, eventually leading to end-stage hear...
Source: Polish Heart Journal - November 7, 2019 Category: Cardiology Authors: Fedorowski A, Ricci F, Sutton R Tags: Kardiol Pol Source Type: research

Antiphosholipid syndrome and the risk of myocardial infarction: current evidence and uncertainties.
Abstract Antiphospholipid syndrome (APS) encompasses a wide spectrum of disease manifestations that may prevail in the form of venous or arterial thrombosis or lead to pregnancy complications in the presence of persisting antiphospholipid (aPL) antibodies. Unlike in the case of congenital thrombophilias where venous thromboses are more likely to occur as compared to arterial events, aPL antibodies may cause thrombosis in both types of vascular system, often including the coronary or cerebral arteries leading to myocardial infarction (MI) or stroke. In this review we summarize the complex pathomechanisms leading to...
Source: Polish Heart Journal - December 5, 2019 Category: Cardiology Authors: Lóczi L, Kappelmayer J, Tarr T, Bagoly Z Tags: Kardiol Pol Source Type: research

Large-vessel occlusion, large thrombus burden acute stroke in acute pulmonary embolism: a single multi-specialty multi-skill team treatment optimization
Kardiol Pol. 2021 Oct 13. doi: 10.33963/KP.a2021.0126. Online ahead of print.NO ABSTRACTPMID:34643256 | DOI:10.33963/KP.a2021.0126
Source: Polish Heart Journal - October 13, 2021 Category: Cardiology Authors: Łukasz Tekieli Tomasz Tomaszewski Robert Musia ł Magdalena Lipi ńska-Strasik Ma łgorzata Urbańczyk-Zawadzka R Pawe ł Banyś Renata Makson Łukasz Wiewiórka Joanna Adamczyk-Dylewska Iris Q Grunwald Piotr Musia łek Source Type: research

Dual pathway inhibition for atherosclerotic cardiovascular disease: Recent advances
Kardiol Pol. 2022;80(12):1200-1210. doi: 10.33963/KP.a2022.0283.ABSTRACTAtherosclerotic cardiovascular disease (ASCVD), which includes coronary artery disease (CAD), cerebrovascular disease, and peripheral arterial disease (PAD) is associated with significant morbidity, mortality, and healthcare costs. Antiplatelet therapy has long been the mainstay of antithrombotic therapy for the prevention of first-ever and recurrent ASCVD events. More recently, however, randomized trials have demonstrated the benefits and cost-effectiveness of a dual pathway inhibition (DPI) strategy in acute and chronic ASCVD. When used in combinatio...
Source: Polish Heart Journal - January 5, 2023 Category: Cardiology Authors: Stephanie Carlin Tim Ac de Vries Andrzej Budaj John Eikelboom Source Type: research

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