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Condition: Dementia
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Total 3025 results found since Jan 2013.
Cytochrome P450-derived eicosanoids in brain: From basic discovery to clinical translation
Adv Pharmacol. 2023;97:283-326. doi: 10.1016/bs.apha.2022.11.002. Epub 2023 Jan 11.ABSTRACTCytochrome P450 metabolism of arachidonic acid produces epoxyeicosatrienoates (EETs) and hydroxyeicosatetraenoates (HETEs). Both classes of eicosanoids play important and opposing roles in brain function and disease. EETs promote vasodilation and exhibit antiinflammatory and cytoprotective properties; their biological action is blunted by metabolism to less active diols by the enzyme soluble epoxide hydrolase (sEH). EETs levels are dysregulated in disease states, primarily due to increased activity of sEH. Inhibition of sEH is a prom...
Source: Advances in Pharmacology - May 26, 2023 Category: Drugs & Pharmacology Authors: Catherine M Davis Aseel H Ibrahim Nabil J Alkayed Source Type: research
Associations of circulating metabolites with cerebral white matter hyperintensities
This study found that the majority of lipoprotein subclasses and lipid concentration are strongly associated with WMH volume, and several non-lipid-related traits such as Gly, MUFA, and degree of unsaturation present certain effects on WMH. In addition, the results revealed the sex and age specificities indicating the distinct metabolomic features impact WMH in diverse individuals. These results demonstrated the power of detailed metabolite profiling for biomarker discovery, which can yield an improved molecular understanding of disease mechanisms. AbstractWhite matter hyperintensities (WMH) are the most compelling risk fa...
Source: Journal of Neurochemistry - May 25, 2023 Category: Neuroscience Authors: Yan Sun,
Yu Guo,
Hong ‐Qi Li,
Lan Tan,
Jian‐Feng Feng,
Wei Cheng,
Jin‐Tai Yu Tags: ORIGINAL ARTICLE Source Type: research
