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Device Closure Versus Medical Therapy Alone for Patent Foramen Ovale in Patients With Cryptogenic Stroke: A Systematic Review and Meta-analysis.
Conclusion: In patients with PFO and cryptogenic stroke, transcatheter device closure decreases risk for recurrent stroke compared with medical therapy alone. Because recurrent stroke rates are low even with medical therapy alone and PFO closure might affect AF risk, shared decision making is crucial for this treatment. Primary Funding Source: None. PMID: 29310136 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - January 9, 2018 Category: Internal Medicine Authors: Shah R, Nayyar M, Jovin IS, Rashid A, Bondy BR, Fan TM, Flaherty MP, Rao SV Tags: Ann Intern Med Source Type: research

In acute ischemic stroke or TIA, adding ticagrelor to aspirin reduced stroke or death and increased severe bleeding.
Abstract SOURCE CITATION: Johnston SC, Amarenco P, Denison H, et al. Ticagrelor and aspirin or aspirin alone in acute ischemic stroke or TIA. N Engl J Med. 2020;383:207-17. 32668111. PMID: 33316187 [PubMed - in process]
Source: Annals of Internal Medicine - December 15, 2020 Category: Internal Medicine Authors: Hill MD Tags: Ann Intern Med Source Type: research

Ticagrelor-Aspirin Versus Clopidogrel-Aspirin Among < em > CYP2C19 < /em > Loss-of-Function Carriers With Minor Stroke or Transient Ischemic Attack in Relation to Renal Function: A Post Hoc Analysis of the CHANCE-2 Trial
CONCLUSION: Patients with normal, rather than impaired, renal function received greater benefit from ticagrelor-aspirin versus clopidogrel-aspirin.PRIMARY FUNDING SOURCE: Ministry of Science and Technology of the People's Republic of China.PMID:36315949 | DOI:10.7326/M22-1667
Source: Annals of Internal Medicine - October 31, 2022 Category: Internal Medicine Authors: Anxin Wang Xuewei Xie Xue Tian S Claiborne Johnston Hao Li Philip M Bath Yingting Zuo Jing Jing Jinxi Lin Yilong Wang Xingquan Zhao Zixiao Li Yong Jiang Liping Liu Xia Meng Yongjun Wang Source Type: research

Adding clopidogrel to aspirin after TIA or minor ischemic stroke reduced stroke without increasing bleeding.
PMID: 24126666 [PubMed - in process]
Source: Annals of Internal Medicine - October 15, 2013 Category: Internal Medicine Authors: Hill MD Tags: Ann Intern Med Source Type: research

Dabigatran increased bleeding and stroke compared with warfarin after mechanical heart valve implantation.
PMID: 24343411 [PubMed - in process]
Source: Annals of Internal Medicine - December 17, 2013 Category: Internal Medicine Authors: Kolias TJ Tags: Ann Intern Med Source Type: research

Review: Aspirin for CVD primary prevention increases gastrointestinal bleeding and hemorrhagic stroke.
PMID: 27538178 [PubMed - in process]
Source: Annals of Internal Medicine - August 15, 2016 Category: Internal Medicine Authors: Fletcher RH Tags: Ann Intern Med Source Type: research

In embolic stroke of undetermined source, rivaroxaban vs aspirin did not reduce recurrence and increased bleeding.
PMID: 30242405 [PubMed - in process]
Source: Annals of Internal Medicine - September 18, 2018 Category: Internal Medicine Authors: Frieden RW Tags: Ann Intern Med Source Type: research

In AF, ABC scores predicted stroke or major bleeding better than CHA2DS2-VASc and HAS-BLED scores, respectively.
PMID: 31207624 [PubMed - in process]
Source: Annals of Internal Medicine - June 17, 2019 Category: Internal Medicine Authors: Kearon C Tags: Ann Intern Med Source Type: research

In older patients with AF, low-dose edoxaban reduced stroke or systemic embolism without increasing major bleeding.
Abstract SOURCE CITATION: Okumura K, Akao M, Yoshida T, et al. Low-dose edoxaban in very elderly patients with atrial fibrillation. N Engl J Med. 2020;383:1735-45. 32865374. PMID: 33395333 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - January 5, 2021 Category: Internal Medicine Authors: Steinberg DI Tags: Ann Intern Med Source Type: research

Left Atrial Appendage Occlusion Versus Oral Anticoagulation in Atrial Fibrillation : A Decision Analysis
CONCLUSION: Although LAAO could be an alternative to anticoagulants for stroke prevention in patients with AF and high bleeding risk, the overall benefit from LAAO depends on the combination of stroke and bleeding risks in individual patients. These results suggest the need for a sufficiently low stroke risk for LAAO to be beneficial. The authors believe that these results could improve shared decision making when selecting patients for LAAO.PRIMARY FUNDING SOURCE: None.PMID:35969865 | DOI:10.7326/M21-4653
Source: Annals of Internal Medicine - August 15, 2022 Category: Internal Medicine Authors: Derek S Chew Ke Zhou Sean D Pokorney David B Matchar Sreekanth Vemulapalli Larry A Allen Kevin P Jackson Zainab Samad Manesh R Patel James V Freeman Jonathan P Piccini Source Type: research

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