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Specialty: Genetics & Stem Cells
Condition: Arthritis
Countries: UK Health
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Rheumatoid Arthritis and Cardio-Cerebrovascular Disease: A Mendelian Randomization Study
Significant genetic association exists between rheumatoid arthritis (RA) and cardiovascular disease. The associated mechanisms include common inflammatory mediators, changes in lipoprotein composition and function, immune responses, etc. However, the causality of RA and vascular/heart problems remains unknown. Herein, we performed Mendelian randomization (MR) analysis using a large-scale RA genome-wide association study (GWAS) dataset (462,933 cases and 457,732 controls) and six cardio-cerebrovascular disease GWAS datasets, including age angina (461,880 cases and 447,052 controls), hypertension (461,880 cases and 337,653 c...
Source: Frontiers in Genetics - October 21, 2021 Category: Genetics & Stem Cells Source Type: research
