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Does an Alzheimer's disease susceptibility gene influence the cognitive effects of cancer therapy?
Abstract The apolipoprotein E (APOE) e4 allele is the most prevalent genetic risk factor for Alzheimer's disease (AD). APOE e4 carriers suffer greater morbidity from head trauma, stroke, and carbon monoxide poisoning, yet possible interactions between APOE genotype and cancer therapy on cognition are unclear. Neuropathological and biomarker studies of young asymptomatic APOE e4 carriers that show elevated neocortical amyloid and medial temporal neurofibrillary tangles and longitudinal neuropsychological studies that show accelerated memory decline beginning around age 55–60 years define preclinical AD and have set the st...
Source: Pediatric Blood and Cancer - September 17, 2013 Category: Cancer & Oncology Authors: Richard J. Caselli Tags: Review Source Type: research