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Nutraceutical induction and mimicry of heme oxygenase activity as a strategy for controlling excitotoxicity in brain trauma and ischemic stroke: focus on oxidative stress
Expert Rev Neurother. 2021 Feb;21(2):157-168. doi: 10.1080/14737175.2021.1861940. Epub 2020 Dec 28.ABSTRACTIntroduction: Ischemic stroke and traumatic brain injury are leading causes of acute mortality, and in the longer run, major causes of significant mental and physical impairment. Most of the brain neuronal cell death in the minutes and hours following an ischemic stroke or brain trauma is mediated by the process of excitotoxicity, in which sustained elevations of extracellular glutamate, reflecting a failure of ATP-dependent mechanism which sequester glutamate in neurons and astrocytes, drive excessive activation of N...
Source: Expert Review of Neurotherapeutics - December 8, 2020 Category: Neurology Authors: Mark F McCarty Aaron Lerner Source Type: research
