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Specialty: Physics
Source: Applied Physics Letters
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The system with zwitterionic lactose-based surfactant for complexation and delivery of small interfering ribonucleic acid—A structural and spectroscopic study
This article presents results of a study on the structural effects associated with siRNA complexation by a surfactant comprising a lactose group (N-(3-propanesulfone)-N-dodecyl-amino-beta-D-lactose hydrochloride, LA12). The double stranded siRNA oligomer (21 base pairs) used in this study is responsible for silencing a gene that can be important in the therapy of myotonic dystrophy type 1. The obtained siRNA/LA12 lipoplexes were studied using the methods of small angle scattering of synchrotron radiation, circular dichroism spectroscopy,
Fourier transform infrared spectroscopy, and electrophoretic mobility tests. ...
Source: Applied Physics Letters - May 24, 2016 Category: Physics Authors: Michalina Skupin, Krzysztof Sobczak, Ryszard Zieliński and Maciej Kozak Source Type: research
