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siRNA release from gold nanoparticles by nanosecond pulsed laser irradiation and analysis of the involved temperature increase
Journal of Biophotonics, EarlyView.
Source: Journal of Biophotonics - May 24, 2018 Category: Physics Authors: Florian Rudnitzki , Susanne Feineis , Ramtin Rahmanzadeh , Elmar Endl , Johanna Lutz , J ürgen Groll , Gereon Hüttmann Source Type: research

Enhancement of extracellular molecule uptake in plasmonic laser perforation
In this study we analyzed the uptake of fluorescent dextrans with sizes from 10 to 2000 kDa, which resembles a wide range of biologically relevant molecules in size using a 532 nm picosecond laser system and 200 nm gold nanoparticles. Our results show a strong uptake‐dependence on cell medium or buffer, but no dominant dependence on osmotic conditions. The relation between pulse energy and number of pulses for a given perforation efficiency revealed that multiphoton ionization of water might contribute to perforation. Moreover, a seven‐fold uptake‐enhancement could be reached with optimized parameters, providing a ve...
Source: Journal of Biophotonics - January 1, 2013 Category: Physics Authors: Stefan Kalies, Tobias Birr, Dag Heinemann, Markus Schomaker, Tammo Ripken, Alexander Heisterkamp, Heiko Meyer Tags: Full Article Source Type: research