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Beta-Amyloid Oligomers Activate Apoptotic BAK Pore for Cytochrome c Release.
Abstract In Alzheimer's disease, cytochrome c-dependent apoptosis is a crucial pathway in neuronal cell death. Although beta-amyloid (Aβ) oligomers are known to be the neurotoxins responsible for neuronal cell death, the underlying mechanisms remain largely elusive. Here, we report that the oligomeric form of synthetic Aβ of 42 amino acids elicits death of HT-22 cells. But, when expression of a bcl-2 family protein BAK is suppressed by siRNA, Aβ oligomer-induced cell death was reduced. Furthermore, significant reduction of cytochrome c release was observed with mitochondria isolated from BAK siRNA-treated HT-22...
Source: Biophysical Journal - October 7, 2014 Category: Physics Authors: Kim J, Yang Y, Song SS, Na JH, Oh KJ, Jeong C, Yu YG, Shin YK Tags: Biophys J Source Type: research