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Rab27a-mediated exosome secretion in anterior cingulate cortex contributes to colorectal visceral pain in adult mice with neonatal maternal deprivation
CONCLUSIONS: This study suggested that overexpression of Rab27a increased exosome secretion in ACC neurons, thus contributing to visceral hyperalgesia in NMD mice.PMID:37529842 | DOI:10.1152/ajpgi.00029.2023
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - August 2, 2023 Category: Physiology Authors: Qian Sun Rui-Xia Weng Jia-Hui Li Yong-Chang Li Ji-Tian Xu Rui Li Xiaomin Lu Guang-Yin Xu Source Type: research

ATF4-mediated CD36 Upregulation Contributes to Palmitate-induced Lipotoxicity in Hepatocytes
In this study, our data revealed for the first time that ATF4 plays a critical role in mediating hepatic CD36 expression. Genetic inhibition of ATF4 attenuated CD36 upregulation induced by either palmitate or ER stress inducer tunicamycin in hepatocytes. In mice, tunicamycin upregulates liver CD36 expression, whereas hepatocyte-specific ATF4 knockout mice manifest lower hepatic CD36 expression when compared to control animals. Furthermore, we demonstrated that CD36 upregulation upon palmitate exposure represents a feedforward mechanism in that siRNA knockdown of CD36 in hepatocytes blunted ATF4 activation induced by both p...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - February 28, 2023 Category: Physiology Authors: Alexandra Griffiths Jun Wang Qing Song Samuel Man Lee Jose Cordoba-Chacon Zhenyuan Song Source Type: research

β-PIX cooperates with GIT1 to regulate eNOS in sinusoidal endothelial cells
CONCLUSIONS: The data indicate that b-PIX regulates eNOS phosphorylation and function in normal SECs, and highlight the importance of the GIT1/b-PIX/eNOS trimolecular complex in normal liver SEC function.PMID:36044673 | DOI:10.1152/ajpgi.00034.2022
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - August 31, 2022 Category: Physiology Authors: Songling Liu Richard T Premont Ki-Hoon Park Don C Rockey Source Type: research

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