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Specialty: Drugs & Pharmacology
Source: Advances in Pharmacology
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Total 63 results found since Jan 2013.
NAPE-specific phospholipase D regulates LRRK2 association with neuronal membranes
Adv Pharmacol. 2021;90:217-238. doi: 10.1016/bs.apha.2020.09.003. Epub 2020 Oct 6.ABSTRACTN-acylphosphatidylethanolamines (NAPEs) are glycerophospholipid precursors for bioactive lipid amides and potential regulators of membrane function. They are hydrolyzed by NAPE-specific phospholipase D (NAPE-PLD) and have been implicated in neurodegenerative disorders such as Parkinson's disease. Here, we used siRNA-mediated silencing of NAPE-PLD in human SH-SY5Y cells and NAPE-PLD-/- mice to determine whether NAPEs influence the membrane association of LRRK2, a multifunctional protein kinase that is frequently mutated in persons with...
Source: Advances in Pharmacology - March 12, 2021 Category: Drugs & Pharmacology Authors: Francesca Palese Silvia Pontis Natalia Realini Daniele Piomelli Source Type: research
