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Role of (Pro)Renin Receptor in Cyclosporin A-Induced Nephropathy
Am J Physiol Renal Physiol. 2022 Jan 24. doi: 10.1152/ajprenal.00332.2021. Online ahead of print.ABSTRACTCalcineurin inhibitors (CNIs) such as cyclosporin A (CsA) have been widely used to improve graft survival following solid-organ transplantation. However, the clinical use of CsA is often limited by its nephrotoxicity. The present study tested the hypothesis that activation of (pro)renin receptor (PRR) contributes to CsA-induced nephropathy by activating the renin-angiotensin system (RAS). Renal injury in male Sprague-Dawley rats was induced by a low-salt diet combined with CsA as evidenced by elevated plasma creatinine ...
Source: American Journal of Physiology. Renal Physiology - January 24, 2022 Category: Physiology Authors: Jiajia Hu Yandan Tan Yanting Chen Shiqi Mo Brittin Hekking Jiahui Su Min Pu Aihua Lu J David Symons Tianxin Yang Source Type: research

Time dependent p53 inhibition determines senescence attenuation and long term outcome after renal ischemia/reperfusion.
In this study we tested the hypothesis that p53 siRNA reduces I/R induced senescence and thereby improves kidney outcome. By comparing the impact of different treatment durations in a mouse model of renal I/R we found that repetitive administration of p53 siRNA during the first 14 days after I/R reduced the senescence load and ameliorated the post-ischemic phenotype. Prolonged application of p53 siRNA over a 26 day period after I/R however, did not provide any additional benefit for senescence reduction, but reversed some of the renoprotective effects of the early treatment. These data suggest a time dependent role of p53 ...
Source: American Journal of Physiology. Renal Physiology - February 20, 2019 Category: Physiology Authors: Baisantry A, Berkenkamp B, Rong S, Bhayadia R, Sörensen-Zender I, Schmitt R, Melk A Tags: Am J Physiol Renal Physiol Source Type: research