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Source: European Journal of Pharmaceutical Sciences
Procedure: Ultrasound
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Total 3 results found since Jan 2013.
Ultrasound-mediated mesoporous silica nanoparticles loaded with PDLIM5 siRNA inhibit gefitinib resistance in NSCLC cells by attenuating EMT
Eur J Pharm Sci. 2023 Jan 5:106372. doi: 10.1016/j.ejps.2023.106372. Online ahead of print.ABSTRACTEpidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKIs) was one of the main drugs in the treatment of non-small cell lung cancer (NSCLC). Previous studies had demonstrated that PDZ and LIM Domain 5 (PDLIM5) played an important role in EGFR TKIs resistance. However, there was no feasible method to eliminate EGFR TKIs resistance by suppressing this gene. Here, we formulated a novel mesoporous silica-loaded PDLIM5 siRNA (Small interfering RNA) nanoplatforms. The results have shown that PDLIM5 siRNA could be effect...
Source: European Journal of Pharmaceutical Sciences - January 9, 2023 Category: Drugs & Pharmacology Authors: Hao Wu Wen-Hao Lv Yang-Yang Zhu Ying-Ying Jia Fang Nie Source Type: research
