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Condition: Peripheral Neuropathy
Procedure: MRI Scan
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Total 1 results found since Jan 2013.
Pmp22 mutant allele-specific siRNA alleviates demyelinating neuropathic phenotype in vivo.
In this study, we investigated whether regulation of a mutant allele by an allele-specific small interfering RNA (siRNA) can alleviate the demyelinating neuropathic phenotype of CMT. We designed 19 different allele-specific siRNAs for Trembler J (Tr-J) mice harboring a naturally occurring mutation (Leu16Pro) in Pmp22. Using a luciferase assay, we identified an siRNA that specifically and selectively reduced the expression level of the mutant allele and reversed the low viability of Schwann cells caused by mutant Pmp22 over-expression in vitro. The in vivo efficacy of the allele-specific siRNA was assessed by its intraperit...
Source: Neurobiology of Disease - January 16, 2017 Category: Neurology Authors: Lee JS, Chang EH, Koo OJ, Jwa DH, Mo WM, Kwak G, Moon HW, Park HT, Hong YB, Choi BO Tags: Neurobiol Dis Source Type: research
