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Abstract 1255: The Mediterranean herb rosemary modulates ER stress proteins to promote androgen receptor degradation in prostate cancer cells
Conclusion: Rosemary induces ER stress-mediated apoptotic cell death in prostate cancer cell lines, 22Rv1and LNCaP cells, leading to disruption of AR expression. Our data suggests that this Mediterranean dietary phytochemical possess strong anticancer activity and should be evaluated further as potential chemopreventive and/or chemotherapeutic agent for controlling prostate cancer. Citation Format: Sakina M. Petiwala, Saba Berhe, Gongbo Li, Angela G. Puthenveetil, Larisa Nonn, Jeremy J. Johnson. The Mediterranean herb rosemary modulates ER stress proteins to promote androgen receptor degradation in prostate cancer cells. [...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Petiwala, S. M., Berhe, S., Li, G., Puthenveetil, A. G., Nonn, L., Johnson, J. J. Tags: Prevention Research Source Type: research

Abstract 4110: Gartanin from the mangosteen fruit modulates androgen receptor and ER stress proteins in prostate cancer cells leading to apoptosis
Conclusions: Our study demonstrated that gartanin inhibited proliferation and induced apoptosis on prostate cancer cells in vitro. It achieves its anticancer effects partly through inhibiting AR and promoting ER stress. The ability of gartanin to inhibit prostate cancer cells suggests further research is needed to evaluate gartanin as a novel agent for the management of prostate cancer. Citation Format: Gongbo Li, Sakina Petiwala, Jeremy Johnson. Gartanin from the mangosteen fruit modulates androgen receptor and ER stress proteins in prostate cancer cells leading to apoptosis. [abstract]. In: Proceedings of the 105th Annua...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Li, G., Petiwala, S., Johnson, J. Tags: Prevention Research Source Type: research

Abstract 2335: Thymoquinone induces the MUC4 mRNA-destabilizing activity of Tristetraprolin
In this study, we investigate that Tymoquinone (TQ) which is an active ingredient derived from the medicinal plant Nigella satia induces the TTP mRNA and protein expression in AGS and MDA-MB231. TQ treatment destabilized a luciferase mRNA containing cIAP2, VEGF and MUC4 ARE. Transfected cells were treated with various kinds of MAPK inhibitors, treatment with Sorafenib (RAF inhibitor) and U0126 (MEK-1/2) reduced the TTP induction activity of TQ in a dose-dependent manner. We confirmed that co-treatment with sorafenib/U0126 and TQ also reduced TTP expression. Following TQ downregulated the expression of MUC4 in previous stud...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Lee, H. H., Lee, S.-R., Leem, S.-H. Tags: Molecular and Cellular Biology Source Type: research