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Source: Infection and Immunity
Infectious Disease: Fungal Infections
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Chitinase 3-Like 1 Promotes Candida albicans Killing and Preserves Corneal Structure and Function by Controlling Host Antifungal Responses Fungal and Parasitic Infections
This study sought to elucidate the role of CHI3L1 in augmenting the corneal innate immune response to Candida albicans infection in an animal model of fungal keratitis. Flagellin applied topically 24 h prior to C. albicans inoculation significantly protected the corneal from C. albicans and induced CHI3L1 expression in C57BL/6 mouse corneas. CHI3L1, however, played a detectable but minor role in flagellin-induced protection. While C. albicans keratitis was more severe in the corneas treated with Chi3l1 small interfering RNA (siRNA), corneas treated with recombinant CHI3L1 before C. albicans inoculation had markedly amelior...
Source: Infection and Immunity - September 10, 2015 Category: Infectious Diseases Authors: Gao, N., Yu, F.-S. X. Tags: Fungal and Parasitic Infections Source Type: research
