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Infectious Disease: Gastroenteritis
Drug: Polymyxin B
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Total 1 results found since Jan 2013.
Lipopolysaccharide (LPS)-induced autophagy is involved in the restriction of Escherichia coli in peritoneal mesothelial cells
Conclusions:
Our findings demonstrated for the first time that LPS-induced autophagy in peritoneal mesothelial cells could enhance the intracellular bactericidal activity and the co-localization of E.coli with autophagosomes. The activation of TLR4 signaling was involved in this process. These results indicate that LPS-induced autophagy may be a cell-autonomous defense mechanism triggered in peritoneal mesothelial cells in response to E.coli infection.
Source: BMC Microbiology - Latest articles - November 13, 2013 Category: Microbiology Authors: Juan WangXiaoran FengYoujia ZengJinjin FanJuan WuZhijian LiXinhui LiuRong HuangFengxian HuangXueqing YuXiao Yang Source Type: research
