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Source: Journal of Biological Chemistry
Infectious Disease: Dengue Fever
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Dengue Virus NS5 Nuclear Localization Cell Biology
In this study, we examined the nuclear localization of NS5 for all four DENV serotypes. We demonstrate for the first time that there are serotypic differences in NS5 nuclear localization. Whereas the DENV-2 and -3 proteins accumulate in the nucleus, DENV-1 and -4 NS5 are predominantly if not exclusively localized to the cytoplasm. Comparative studies on the DENV-2 and -4 NS5 proteins revealed that the difference in DENV-4 NS5 nuclear localization was not due to rapid nuclear export but rather the lack of a functional nuclear localization sequence. Interaction studies using DENV-2 and -4 NS5 and human importin-α isoforms f...
Source: Journal of Biological Chemistry - August 2, 2013 Category: Chemistry Authors: Hannemann, H., Sung, P.-Y., Chiu, H.-C., Yousuf, A., Bird, J., Lim, S. P., Davidson, A. D. Tags: Microbiology Source Type: research
