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The hub protein loquacious connects the microRNA and short interfering RNA pathways in mosquitoes
Aedes aegypti mosquitoes vector several arboviruses of global health significance, including dengue viruses and chikungunya virus. RNA interference (RNAi) plays an important role in antiviral immunity, gene regulation and protection from transposable elements. Double-stranded RNA binding proteins (dsRBPs) are important for efficient RNAi; in Drosophila functional specialization of the miRNA, endo-siRNA and exo-siRNA pathway is aided by the dsRBPs Loquacious (Loqs-PB, Loqs-PD) and R2D2, respectively. However, this functional specialization has not been investigated in other dipterans. We were unable to detect Loqs-PD in Ae....
Source: Nucleic Acids Research - April 19, 2015 Category: Research Authors: Haac, M. E., Anderson, M. A. E., Eggleston, H., Myles, K. M., Adelman, Z. N. Tags: Molecular Biology Source Type: research