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Source: AJP: Lung Cellular and Molecular Physiology
Procedure: Lung Transplant
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Histone deacetylation contributes to low extracellular superoxide dismutase expression in human idiopathic pulmonary arterial hypertension
Epigenetic mechanisms, including DNA methylation and histone acetylation, regulate gene expression in idiopathic pulmonary arterial hypertension (IPAH). These mechanisms can modulate expression of extracellular superoxide dismutase (SOD3 or EC-SOD), a key vascular antioxidant enzyme, and loss of vascular SOD3 worsens outcomes in animal models of pulmonary arterial hypertension. We hypothesized that SOD3 gene expression is decreased in patients with IPAH due to aberrant DNA methylation and/or histone deacetylation. We used lung tissue and pulmonary artery smooth muscle cells (PASMC) from subjects with IPAH at transplantatio...
Source: AJP: Lung Cellular and Molecular Physiology - June 30, 2016 Category: Respiratory Medicine Authors: Nozik-Grayck, E., Woods, C., Stearman, R. S., Venkataraman, S., Ferguson, B. S., Swain, K., Bowler, R. P., Geraci, M. W., Ihida-Stansbury, K., Stenmark, K. R., McKinsey, T. A., Domann, F. E. Tags: ARTICLES Source Type: research
